Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

(2 customer reviews)

 85,000.00

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Actemra Infusion contains Tocilizumab | belongs to Cytokine modulator

SKU: pg_258_322 Categories: , ,

Alternate brands of Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

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Actemra Infusion 80 mg/4 mL 1 Vialx4 mL  11,952.00 You can save 73048
Actemra Infusion 400 mg/20 mL 1 Vialx20 mL  115,000.00 You will pay -30000 more
Actemra Infusion SC 162 mg/0.9 mL 4 Vial  76,849.00 You can save 8151
List of alternate brands

2 reviews for Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

  1. Zahid Iqbal

    Zahid Iqbal submitted 5 stars.

  2. maak

    maak submitted 5 stars.

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How it works

Actemra Infusion 200 mg/10 mL 1 Vialx10 mL works by reducing the effect of certain specific substances in the body that cause inflammation (pain, redness, swelling, stiffness, etc.) in arthritic conditions.

Side effects

Major & minor side effects for Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

  • Mild fever and chills
  • High blood pressure
  • Skin rash and itching
  • Headache
  • Flu like symptoms severe
  • Sore throat
  • Nausea and Vomiting
  • Stomach pain
  • Constipation
  • Mouth blisters
  • Joint pain severe
  • Difficult and painful breathing severe
  • Severe light-headedness severe
  • Severe skin rash and hives severe
  • Black or tarry stools severe
  • Bloody or coffee colored vomit severe
  • Blurred vision severe
  • Bloody or cloudy urine severe
  • Change in heart rate severe
  • Unusual bleeding or bruising severe
  • Loss of appetite
  • Injection site bruising and red coloration
  • Loss of consciousness severe
  • Skin blistering
  • Diarrhea

Uses of Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

What is it prescribed for?

  • Rheumatoid Arthritis

    This medicine is indicated for the treatment of rheumatoid arthritis, an immune disorder characterized by pain and swelling of joints. It is normally used when other disease-modifying anti-rheumatoid medications are not effective.

  • Giant cell arteritis

    This medicine is indicated for the treatment of giant cell arteritis, a condition where blood vessels, particularly in the head and scalp area, become swollen.

  • Polyarticular juvenile idiopathic arthritis

    This medicine is indicated for the treatment of polyarticular juvenile idiopathic arthritis, an arthritic condition in children characterized by swollen and painful joints. It should only be used in children aged 2 years or above.

  • Systemic juvenile idiopathic arthritis

    This medicine is indicated for the treatment of systemic juvenile idiopathic arthritis, an inflammatory condition causing fever, pain, swelling, and developmental abnormalities of different parts of the body in children aged 2 years and above.

  • Cytokine release syndrome

    This medicine is used for the treatment of cytokine release syndrome, a severe and life-threatening reaction that usually develops after receiving certain immunotherapy medications via infusion.

Concerns

Frequently asked questions

  • Onset of action

    The amount of time required for this medicine to show its action is not clinically established.

  • Duration of Effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the potential benefits and risks associated with use should be carefully evaluated. Your doctor may prescribe an alternative medicine based on your clinical condition.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to Actemra Infusion 200 mg/10 mL 1 Vialx10 mL or any other inactive ingredients present along in the formulation. It is also not recommended for use if you have a history of allergy to any other recombinant human or humanized antibodies or proteins that are of hamster origin.

  • Active severe infection

    This medicine is not recommended for use in patients suffering from an active severe infection due to the increased risk of worsening of the patient's condition.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the potential benefits and risks associated with use should be carefully evaluated. Your doctor may prescribe an alternative medicine based on your clinical condition.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

General Warnings
  • Low blood cell counts

    This medicine is not recommended for use in patients with lower values of absolute neutrophil count and platelet counts. Monitoring of these levels is necessary every 4-8 weeks while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

  • Elevated liver enzymes

    This medicine is not recommended for use in patients with ALT and AST levels more than 1.5 times of the upper limit of normal. Monitoring of these levels is necessary every 4-8 weeks while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

  • Lipid abnormalities

    This medicine is not recommended for use in patients with higher levels of triglycerides or cholesterol. Monitoring of these levels is necessary every 4-8 weeks while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

  • Immune suppression

    Usage of this medicine weakens your immune system, thereby increasing the chances of opportunistic infections. Suitable preventive measures should be adopted to avoid such infections.Usage of this medicine weakens your immune system, thereby increasing the chances of opportunistic infections. Suitable preventive measures should be adopted to avoid such infections.

  • Vaccinations

    Vaccinations with live or attenuated strains of micro-organisms should be avoided while taking this medicine due to the increased risk of worsening of the patient’s condition. Similarly, treatment with this medicine should not be initiated if the patient has been vaccinated recently.

  • Other medicines

    Actemra 80 mg Injection may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

  • Heart diseases

    This medicine should be used with caution in patients who are suffering from heart diseases due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.

  • Driving or operating machinery

    Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

  • Intravenous administration

    When used intravenously, this medicine should be infused over a duration of at least 60 minutes.

Dosage

  • Missed Dose

    Infusion: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. Subcutaneous injection: Administer the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

  • Overdose

    Infusion: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected. Subcutaneous injection: Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Live vaccines severe
  • Adalimumab severe
  • Amlodipine moderate
  • Phenytoin moderate
  • Theophylline moderate
  • Cyclosporine moderate
  • Warfarin moderate
  • Atorvastatin severe
Disease interactions
  • severe

    This medicine should be used with extreme caution in patients with a history of recent infections and it is not recommended for use in case of active infections due to the increased risk of worsening of the patient’s condition. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.

  • severe

    This medicine is not recommended for use in patients with demyelinating disorders such as chronic inflammatory demyelinating polyneuropathy or multiple sclerosis due to the increased risk of worsening of the patient’s condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment may be necessary in some cases based on the clinical condition of the patient.

  • severe

    This medicine should be used with caution in patients with gastrointestinal perforations due to the increased risk of worsening of the patient’s condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.

  • moderate

    This medicine should be used with caution in patients with liver diseases. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

  • moderate

    This medicine should be used with caution in patients with kidney diseases. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

General Instructions

Infusion: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Subcutaneous injection: Follow all the instructions given by your doctor and administer this medicine exactly as advised. Do not administer in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information>

How to use Actemra Infusion 200 mg/10 mL 1 Vialx10 mL

Dilute to 100 mL and give by IV infusion over 1 hour. For children, dilute to 100 mL (50 mL if lt;30 kg) and given by IV infusion over 1 hour.
Stability: Refrigerate at 2°C-8°C (36°F-46°F). Do not freeze. Protect the vials from light by storage in the original package until time of use. The fully diluted solutions may be stored at 2°C-8°C or room temperature for up to 24 hours and should be protected from light. Unused product remaining in the vials should not be used.

what are the adverse effects of Actemra Infusion 200 mg/10 mL 1 Vialx10 mL?

Infections, headache, hypertension, raised liver enzymes and bilirubin, weight gain, GI upset, mouth ulceration, rash, pruritus, urticaria, dizziness, blood dyscrasias, hypercholesterolaemia, peripheral oedema, cough, dyspnoea.

What happens if I miss a dose of Actemra Infusion 200 mg/10 mL 1 Vialx10 mL?

Adults: Rheumatoid arthritis: By IV infusion initially 4 mg/kg, may be increased to 8 mg/kg (max 800 mg) once every 4 wk.
Children: Active systemic juvenile idiopathic arthritis, in combination with methotrexate or alone if methotrexate inappropriate) who have had an inadequate response to NSAIDs and systemic corticosteroids: IV infusion: 2-18 yr body-weight less than 30 kg, 12 mg/kg once every 2 wk; review treatment if no improvement within 6 wk; body-weight over 30 kg, 8 mg/kg once every 2 wk; review treatment if no improvement within 6 wk.
Polyarticular juvenile idiopathic arthritis, in combination with methotrexate or alone if methotrexate inappropriate who have had an inadequate response to methotrexate: IV infusion: 2-18 yr body-weight less than 30 kg, 10 mg/kg once every 4 wk; review treatment if no improvement within 12 wk; body-weight over 30 kg, 8 mg/kg once every 4 wk; review treatment if no improvement within 12 wk.

One of the following licensed pharmacy from the nearest location will deliver Actemra Infusion 200 mg/10 mL 1 Vialx10 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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