Aminophylline Injection 250 mg 50 Ampx10 mL

 520.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 250 mg
Drug Form : Injection
Pack Size : 50 Ampx10 mL
Does this requires a prescription ?Yes

Aminophylline Injection contains Aminophylline | belongs to Xanthine

SKU: pg_1001_1242 Category:

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    How it works

    Aminophylline Injection 250 mg 50 Ampx10 mL works by relaxing the smooth vessels of the airways in the lungs. It also reduces the sensitivity of lungs to allergens that cause irritation and constriction of muscles in the chest and the lungs. It also causes the contraction if diaphragm (the breathing muscle present below the lungs).

    Side effects

    Major & minor side effects for Aminophylline Injection 250 mg 50 Ampx10 mL

    • Increased/Irregular heart rate severe
    • Convulsions (seizures) severe
    • Allergic Skin Reaction severe
    • Stomach discomfort and pain
    • Diarrhea
    • Headache
    • Sleeplessness
    • Swelling of ankles or feet
    • Yellowing of skin and eyes severe
    • Increased urination frequency
    • Twitching and unusual movement of muscles severe
    • Elevated liver enzymes

    Uses of Aminophylline Injection 250 mg 50 Ampx10 mL

    What is it prescribed for?

    • Asthma (Acute)

      This medicine is used for the prevention and treatment of symptoms associated with chronic asthma. Symptoms may include wheezing, chest tightness and difficulty in breathing. It is used in conjugation with other medicines to treat emergency conditions.

    • Other lung diseases causing bronchospasms

      This medicine is also used to treat airway blockage associated with other disease of the lungs like chronic bronchitis, emphysema etc. It is used in conjugation with other medicines to treat emergency conditions.

    Concerns

    Frequently asked questions

    • Onset of action

      The amount of time taken for this medicine to show its effect is subject to vary based on the form of medicine consumed.

    • Duration of Effect

      The time duration for which this medicine remains effective in the body is subject to variations based on the form of medicine consumed.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      Usage in pregnancy?

    • Usage in pregnancy?

      This medicine is not recommended for use by women who are pregnant unless absolutely necessary and the benefits outweigh the risks associated. Consult your doctor before using this medicine.

    • Usage while breast-feeding?

      This medicine is not recommended for use by women who are breastfeeding unless necessary. Consult your doctor and discuss the risks associated with use before taking this medicine.

    When not to use?

    • Allergy

      This medicine is not recommended for use if you have a known history of allergy to Aminophylline Injection 250 mg 50 Ampx10 mL or any other xanthine derivatives. It should not be used if you are allergic to ethylenediamine, which is a secondary constituent in the medicine.

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is not recommended for use by women who are pregnant unless absolutely necessary and the benefits outweigh the risks associated. Consult your doctor before using this medicine.

    • Breast-feeding

      This medicine is not recommended for use by women who are breastfeeding unless necessary. Consult your doctor and discuss the risks associated with use before taking this medicine.

    General Warnings
    • Other diseases

      Report the instance of any disease of the heart and blood vessels, brain, thyroid glands etc to the doctor before receiving this medicine. This medicine should be used with caution and any disease worsening symptom should be reported to the doctor immediately.

    • Other medicines

      This medicine is known to interact with a large number of other medicines. Report the use of all medicines including herbs and supplement to the doctor.

    • Smoking

      This medicine tends to be less effective if you smoke or consume tobacco products. Avoid or limit the uptake of tobacco products while taking this medicine.

    • Caffeine

      Consumption of caffeine while taking this medicine may cause certain side effects to appear. Avoid or limit the uptake of caffeine or caffeine products while taking this medicine.

    • Fever and infections

      This medicine should be used with caution if you have a high fever (febrile) with a headache, chills, and joint pain. Report any such instance to the doctor while taking this medicine.

    • Toxic accumulation of the medicine

      Use of high doses of this medicine has been associated with toxicity due to an accumulation of the medicine in the body after long term use. It is advised to measure the serum levels and withhold the dose of this medicine if toxicity symptoms are developed.

    • Use in the elderly

      This medicine should be used with caution in the elderly as the risk of adverse effects are significantly higher.

    • Acute asthma attack

      It is advised to take an alternate and fast-acting medicine to treat an attack of asthma that has already set in.

    Dosage

    • Missed Dose

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

    • Overdose

      Contact your doctor immediately if an overdose with Aminophylline Injection 250 mg 50 Ampx10 mL is suspected. The overdose may occur due to excessive uptake at one time or exposure to high doses over a long period of time. Symptoms of overdose may include fever, nausea and occasional vomiting, lack of sleep, agitation etc. An overdose of this medicine can cause severe seizures and even death.

    Interactions

    Interaction with Medicines
    • Carbamazepine moderate
    • Fluvoxamine severe
    • Lithium moderate
    • Phenytoin severe
    • Propranolol moderate
    • Ethinyl Estradiol moderate
    • Azithromycin moderate
    • Cimetidine severe
    • Ciprofloxacin severe
    • Riociguat severe
    Disease interactions
    • severe

      This medicine should be administered with caution in patients with active peptic ulcer disease. As the risk of worsening of symptoms is very high, your doctor will determine the best course of treatment after assessing the condition.

    • moderate

      This medicine should be used with caution in patients suffering from an impairment of kidney functions. Appropriate dose adjustments and intensive monitoring may be required if the impairment is moderate to severe.

    • severe

      This medicine should be used with caution in patients suffering from seizure disorders. Appropriate medicine to control seizure should be given before starting the treatment with this medicine.

    • moderate

      This medicine should be used with caution in a patient suffering from a heart rhythm disorder. Suitable clinical investigations should be performed to determine the safe and effective use of this medicine.

    • moderate

      This medicine should be used with caution in patients suffering from this rare genetic disorder of the blood and the skin.

    General Instructions

    Avoid or limit the uptake of caffeine while taking this medicine. Report any incidence of an adverse effect to the doctor on priority.

    Other details

    • To be taken on an empty stomach
    • To be taken as instructed by doctor
    • May cause sleepiness

    References

    Additional Information>

    How to use Aminophylline Injection 250 mg 50 Ampx10 mL

    Dilute with IV fluid to a conc. of 1 mg/mL and infuse over 20-30 min; maximum conc: 25 mg/mL; maximum rate of infusion: 0.36 mg/kg/min and not greater than 25 mg/min.
    Compatibility: D5W, NS. Incompatible with amiodarone, ciprofloxacin, diltiazem, dobutamine, hydralazine, or ondansetron into the Y-port of a continuous infusion of aminophylline.
    Stability: Store between 15°C-30°C (59°F-86°F). Protect from light. Discard unused portion.

    what are the adverse effects of Aminophylline Injection 250 mg 50 Ampx10 mL?

    Nausea, gastric irritation, headache, CNS stimulation, hypotension, arrhythmias and convulsions especially if given rapidly by IV injection.

    What happens if I miss a dose of Aminophylline Injection 250 mg 50 Ampx10 mL?

    Plasma-theophylline concentration for optimum response 10-20 mg/Litre (55-110 micro mol/litre); measure plasma-theophylline concentrate 4-6 hr after dose by mouth and at least 5 days after starting oral treatment; measure plasma-theophylline concentration 4-6 hr after the start of intravenous infusion; narrow margin between therapeutic and toxic dose
    INJECTION: Severe acute asthma or acute exacerbation of chronic obstructive pulmonary disease in patients not previously treated with theophylline: Adults: By slow IV injection over at least 20 min (with close monitoring), 250-500 mg (5 mg/kg), then adjusted according to requirement and plasma-theophylline concentration.
    Children: Under 12 yr, 5 mg/kg, then adjusted according to requirement and plasma-theophylline concentration.
    Severe acute asthma or acute exacerbation of chronic obstructive pulmonary disease: By IV infusion (with close monitoring). Adults: 500-700 mcg/kg/hr, adjusted according to plasma-theophylline concentration. Elderly: 300 mcg/kg/hr. Children: Under 12 yr, 1 mg/kg/hr, adjusted according to plasma-theophylline concentration.
    ORAL: Adults & Children: Body wt gt;40 kg: 225 mg initially twice daily; increased after one wk to 450 mg twice daily according to plasma-theophylline concentration.

    One of the following licensed pharmacy from the nearest location will deliver Aminophylline Injection 250 mg 50 Ampx10 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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