27.06

Content Details
Information on this page was last modified on : 2020/06/29 2:00:58 PM

Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

Dexamethasone Injection contains Dexamethasone, Inj/Oral | belongs to Corticosteroid

[display_substitute]

How it works

Dexamethasone Injection 4 mg/mL 25 Ampx1 mL works by decreasing the release of certain substances that cause swelling. It also works by suppressing or partially preventing the effect of the immune system.

Side effects

Major & minor side effects for Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

  • Severe allergic reaction severe
  • Swelling of face, lips, eyelids, tongue, hands and feet severe
  • Loss of vision or blurred vision severe
  • Infections that persist for long severe
  • Black or tarry stools severe
  • Unusual tiredness and weakness
  • Headache
  • Dizziness
  • Sleeplessness
  • Agitation and anxiety
  • Acne
  • Increased hair growth
  • Irregular menstrual periods
  • Easy bruising and bleeding

Uses of Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

What is it prescribed for?

  • Inflammation

    This medicine is used to reduce or prevent swelling associated with conditions like asthma, colitis, allergic skin reactions etc.

  • Joint inflammation

    This medicine is used to relieve swelling and pain associated with diseases like arthritis, rheumatoid arthritis, osteoarthritis, bursitis, tendonitis, gout etc.

  • Eye/Ear inflammation

    This medicine is used to relieve swelling, irritation, burning of the eye and ears caused due to infections, allergy, exposure to chemicals etc.

  • Chemotherapy induced nausea and vomiting

    This medicine is used to prevent nausea and vomiting associated with the use of chemotherapy medicines for the treatment of cancer.

  • Bacterial Meningitis

    This medicine is used along with other antibiotics to relieve the symptoms of meningitis in children.

  • Cushing's syndrome

    This medicine is used as a diagnostic test for Cushing's syndrome.

  • Immunosuppression

    This medicine is used in the prevention immune response under certain specific conditions like Lupus, Psoriasis, Multiple sclerosis, Alopecia etc.

  • Cerebral edema

    This medicine is used for the management of this condition where an excess of water gets accumulated in the brain.

  • Shock

    This medicine is used in the management of shock where the patient is unresponsive.

  • Cancer

    This medicine is also used for the management of certain specific forms of cancer like Multiple myeloma, brain tumors etc.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed within a few minutes after oral administration. However, this is subject to vary widely depending upon the form of administration and intended use.

  • Duration of Effect

    The effect of this medicine lasts based on the form of administration and intended use.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    Use of this medicine is not recommended for pregnant women unless absolutely necessary and the potential benefits outweigh the risk involved. Consult your doctor before using this medicine.

  • Usage while breast-feeding?

    Use of this medicine is not recommended by breastfeeding women unless absolutely necessary and the potential benefits outweigh the risk involved. Consult your doctor before using this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use if you have a known history of allergy to it or any other medicine belonging to the category of corticosteroids.

  • Systemic Fungal Infection

    This medicine is not recommended for use if you have a fungal infection affecting an internal organ/organs in the body.

  • Cerebral malaria

    This medicine is not recommended for use if you are suffering from a rare type of malaria that affects the brain.

  • Active untreated infection

    This medicine is not recommended for use in patients suffering from any serious infection and is yet to receive any treatment for the same.

Warnings

Warnings for special population
  • Pregnancy

    Use of this medicine is not recommended for pregnant women unless absolutely necessary and the potential benefits outweigh the risk involved. Consult your doctor before using this medicine.

  • Breast-feeding

    Use of this medicine is not recommended by breastfeeding women unless absolutely necessary and the potential benefits outweigh the risk involved. Consult your doctor before using this medicine.

Warnings

Warnings for special population
  • Other medicines

    This medicine may interact with any medicine that you might be possible taking. Report the use of all medicines including supplement and herbs to the doctor to ensure safe and effective use of this medicine.

  • Allergic reaction

    This medicine has the potential of causing moderate to a severe allergic reaction in the body. Any instance indicative of allergic reactions should be reported to the doctor in the first instance.

  • Other diseases

    This medicine should be used with caution if the patient is suffering from diseases like cirrhosis, diverticulitis, myasthenia gravis, peptic ulcer disease, kidney diseases etc. Report the instance of other diseases as well before treatment with this medicine is initiated.

  • Change in blood pressure

    Use of large dose of this medicine can alter the levels of electrolytes like sodium and potassium in the body and may cause unexpected changes in blood pressure levels.

  • Withdrawal symptoms

    Use of this medicine should not be abruptly stopped as the patient is likely to suffer from withdrawal symptoms. The use should be slowly and gradually withdrawn.

  • Systemic fungal infections

    Use of this medicine may worsen the symptoms of internal fungal infections and hence should be used only under life-threatening circumstances.

  • Lowest possible dose

    The lowest possible dose of this medicine should be taken to keep the interactions and side effects away. Hence it is advised to optimize the dose strength at the earliest by accessing the underlying condition.

  • Growth inhibition

    This medicine should be used with caution in pediatric patients as the risk of growth abnormalities, brittle bones, and other developmental problems are significantly high.

  • Psychotic effects

    Use of this medicine can cause side effects like agitation, anxiety, depression, mood changes, and other psychotic manifestations and hence caution is advised. Any sign and symptom indicative of a mental side effect should be reported to the doctor immediately.

  • Delayed wound healing

    Use of this medicine may delay the process of wound healing.

  • Immunization procedures

    Immunization procedures involving the injection of a live and weakened pathogen should be avoided while taking this medicine. Alternate means of immunization not involving a live strain of a microorganism could be considered.

Dosage

  • Missed Dose

    Contact your doctor for instructions if you missed a scheduled dose of this medicine. A self-attempt to make up for the lost dose may result in adverse effects.

  • Overdose

    Contact your doctor if an overdose with this medicine for is suspected especially when the prescribed dose is very high. Symptoms may include thinning of the skin, easy bruising and bleeding, body fat deposits etc.

Interactions

Interaction with Medicines
  • Deflazacort severe
  • Levofloxacin severe
  • Live attenuated vaccines and related products severe
  • Hydrocodone severe
Disease interactions
  • severe

    This medicine is known to cause imbalances in the levels of minerals like calcium, potassium, and sodium in the body. Hence it should be administered with caution in patients with a pre-existing electrolyte imbalance disorder.

  • severe

    This medicine is known to cause perforations and bleeding in the gut especially when high doses are consumed. Hence this medicine should be administered with caution in patients having a pre-existing perforation disorder of the stomach or intestine.

  • severe

    This medicine should be used with caution in patients who have recovered or are recovering from a recent heart attack.

  • severe

    This medicine should be used with caution if the patient is suffering from an eye infection caused by herpes simplex virus.

  • severe

    This medicine should be used with caution in patients suffering from this disease where the skin and connective tissue beneath become hard and stiff.

  • severe

    This medicine should be used with caution in patients suffering from an infection caused by threadworm (Strongyloides).

Lab interactions

General Instructions

Take Dexamethasone Injection 4 mg/mL 25 Ampx1 mL as instructed by the doctor. Your dosage timings, forms, duration and other attributes are subject to vary depending on the condition and hence adherence to the instruction is necessary to ensure safe and effective use of this medicine.

Other details

  • Food timings: Information not available
  • Administration time: Information not available
  • Sleep inducing: Information not available

References

How to use Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

IV: Administer IV as a 5-10 mins bolus; do not administer rapid IV inj. Inject undiluted IV dose directly into IV tubing of infusing compatible solution over 30 sec or less, as prescribed. IM: Shake IM solution before injecting deep into large muscle mass.
Reconstitution: Injection should be diluted in 50-100 mL NS or D5W.
Compatibility: Stable in D5W or NS.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, aztreonam, bumetanide, cephazolin, cefepime, ceftriaxone, cimetidine, cisatracurium, diltiazem, dopamine, enalapril, epinephrine, famotidine, fentanyl, fluconazole, furosemide, heparin, hydrocortisone, imipenem, insulin regular, ketorolac, lansoprazole, levofloxacin, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, milrinone, morphine, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, piperacillin/tazobactam, propofol, vasopressin.
Drug to Drug IV Incompatibility: Calcium gluconate, ciprofloxacin, diphenhydramine, dobutamine, esmolol, gentamicin, idarubicin, labetalol, midazolam, pantoprazole, tobramycin, topotecan.
In syringe: Incompatible with doxapram, glycopyrrolate.
When admixed: Incompatible with daunorubicin, diphenhydramine with lorazepam and metoclopramide, metaraminol, vancomycin.
Stability: Store at 25°C with excursions permitted between 15°C-30°C. The product is sensitive to heat. Do not autoclave. Protect from freezing and light. Store container in carton until contents have been used because infusion solutions generally do not contain preservatives, mixtures should be used within 24 hours.

UNLICENSED USE
Adults: Dexamethasone suppression test (depression/suicide indicator): Oral: 1 mg at 11 PM, draw blood at 8 AM the following day for plasma cortisol determination.
Acute mountain sickness/high altitude cerebral edema: Prevention: Oral: 2 mg every 6 hrs or 4 mg every 12 hrs starting on the day of ascent; may be discontinued after staying at the same elevation for 2-3 days or if descent is initiated; do not exceed a 10 day duration. Treatment: Oral/IM/IV: Acute mountain sickness: 4 mg every 6 hrs. High altitude cerebral edema: Initial 8 mg as a single dose; Maintenance 4 mg every 6 hrs until symptoms resolve.

what are the adverse effects of Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

Endocrine irregularities including menstrual problems, Cushingoid state, adrenal suppression, growth suppression in children. Increased susceptibility to infection, increased severity of infection. Fluid/electrolyte disturbance, hypertension, negative protein, nitrogen and calcium balance. Myopathy, tendon rupture, osteoporosis, osteonecrosis and fractures. Impaired wound healing, sweating, hirsutism, striae, telangiectasia, acne. GI disturbance, peptic ulceration, acute pancreatitis, candidiasis. Psychiatric effects, neurological effects, insomnia. Diabetes, impaired glucose tolerance, weight gain, increased appetite. Ocular disturbances including cataracts, raised intraocular pressure, optic nerve damage, corneal changes, glaucoma. Thromboembolism, leukocytosis.

What is the dose of Dexamethasone Injection 4 mg/mL 25 Ampx1 mL

Note: Dexamethasone 1 mg equiv to dexamethasone phosphate 1.2 mg equiv to dexamethasone sodium phosphate l.3 mg.
Adults: Antiemetic: Prophylaxis: Oral/IV: 10-20 mg 15-30 min before treatment on each treatment day. Continuous infusion regimen: IV: 10 mg every 12 hrs on each treatment day. Mildly emetogenic therapy: Oral/IM/IV: 4 mg every 4-6 hrs. Delayed nausea vomiting: Oral: 4-10 mg 1-2 times/day for 2-4 days or 8 mg every 12 hrs for 2 days; then 4 mg every 12 hrs for 2 days or 20 mg 1 hr before chemotherapy; then 10 mg 12 hrs after chemotherapy; then 8 mg every 12 hrs for 4 doses; then 4 mg every 12 hrs for 4 doses.
Anti-inflammatory: Oral/IM/IV (inj as sodium phosphate): 0.75-9 mg/day in divided doses every 6-12 hrs. Intra-articular, intralesional, or soft tissue (as sodium phosphate): 0.4-6 mg/day.
Multiple myeloma: Oral/IV: 40 mg/day, days 1 to 4, 9 to 12, & 17 to 20, repeated every 4 wks (alone or as part of a -regimen).
Cerebral oedema: IV: 10 mg stat, 4 mg IM/IV every 6 hrs until response is maximized, then switch to oral regimen, then taper off if appropriate; dosage may be reduced after 2-4 days & gradually discontinued over 5-7 days.
Extubation or airway oedema: Oral/IM/IV: (inj as sodium phosphate): 0.5-2 mg/kg/day in divided doses every 6 hrs beginning 24 hrs prior to extubation & continuing for 4-6 doses afterwards.
Cushing’s syndrome, diagnostic: Oral: 0.5 mg by mouth every 6 hrs for 48 hrs (with 24-hr urine collection for 17-hydroxycorticosteroid excretion). Differentiation of Cushing’s syndrome due to ACTH excess from Cushing’s due to other causes: Dexamethasone 2 mg every 6 hrs for 48 hrs (with 24-hr urine collection for 17-hydroxycorticosteroid excretion).
Multiple sclerosis (acute exacerbation): 30 mg/day for 1 wk, followed by 4-12 mg/day for 1 mth.
Physiological replacement: Oral/IM/IV (as sodium phosphate): 0.03-0.15 mg/kg/day or 0.6-0.75 mg/square meter/day in divided doses every 6-12 hrs.
Treatment of shock: Addisonian crisis/shock: IV (as sodium phosphate): 4-10 mg as a single dose, which may be repeated if necessary. Unresponsive shock (unresponsive to steroid therapy): IV (as sodium phosphate): 1-6 mg/kg as a single IV dose or up to 40 mg initially followed by repeat doses every 2-6 hrs while shock persists.
Children: Inflammatory & allergic disorders: Oral: 1 mth-18 yr, 10-100 mcg/kg daily in 1-2 divided doses, adjusted according to response; up to 300 mcg/kg daily may be required in emergency situations. IM injection or IV injection or infusion: 1 mth-12 yr, 83-333 mcg/kg daily in 1-2 divided doses, max 20 mg daily; 12-18 yr, initially 0.4-20 mg daily.
Life-threatening cerebral oedema: IV injection: Under 35 kg body-weight, initially 16.7 mg, then 3.3 mg every 3 hr for 3 days, then 3.3 mg every 6 hr for 1 day, then 1.7 mg every 6 hr for 4 days, then decrease by 0.8 mg daily; Over 35 kg body-weight, initially 20.8 mg, then 3.3 mg every 2 hr for 3 days, then 3.3 mg every 4 hr for 1 day, then 3.3 mg every 6 hr for 4 days, then decrease by 1.7 mg daily.
Bacterial meningitis: IV injection: 3 mth-18 yr, 150 mcg/kg (max 10 mg) every 6 hr for 4 days starting before or with first dose of antibacterial.
Physiological replacement: Oral or IV injection: 1 mth-18 yr, 250-500 mcg/square meter every 12 hr, adjusted according to response.
Croup: Mild croup is largely self-limiting: Oral: Single dose of dexamethasone 150 mcg/kg. Severe croup (or mild croup that might cause complications), single dose of dexamethasone 150 mcg/kg can be administered by mouth before transfer to hospital. In hospital, dexamethasone 150 mcg/kg (by mouth or by injection); the dose may be repeated after 12 hr if necessary.

One of the following licensed pharmacy from the nearest location will deliver Dexamethasone Injection 4 mg/mL 25 Ampx1 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

Want to share this information?
Facebook
Twitter
LinkedIn
Something doesn't feel right ?

Reviews

There are no reviews yet.

Be the first to review “Dexamethasone Injection 4 mg/mL 25 Ampx1 mL”

Questions and answers of the customers

There are no questions yet. Be the first to ask a question about this product.

Only registered users are eligible to enter questions
Recent reviews
میڈیکل اسٹور مالکان کے لئے ھول سیل ریٹس پرفری ڈیلوری