Epotin Injection 4000 IU 1 Vial

 2,000.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 4000 IU
Drug Form : Injection
Pack Size : 1 vial
Does this requires a prescription ?Yes

Epotin Injection contains Epoetin Alfa | belongs to Recombinant human erythropoietin

SKU: pg_7668_10622 Categories: ,

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    How it works

    Epotin Injection 4000 IU 1 Vial works by stimulating the bone marrow and as a result production of red blood cells is increased.

    Side effects

    Major & minor side effects for Epotin Injection 4000 IU 1 Vial

    • Fever
    • Nausea
    • Vomiting
    • Mouth sores
    • Headache
    • Muscle or joint pain
    • Cough
    • Diarrhea
    • Swelling and redness at the injection site
    • Stomach discomfort and pain
    • Severe skin allergy severe
    • Swelling of face, lips, eyelids, tongue, hands and feet severe
    • Difficulty in breathing severe
    • Wheezing severe
    • Dizziness and fainting severe
    • Upper respiratory tract infection
    • Difficulty in swallowing severe
    • Increased blood pressure
    • Pure red cell aplasia severe

    Uses of Epotin Injection 4000 IU 1 Vial

    What is it prescribed for?

    • Chronic kidney disease associated anemia

      Epotin Injection 4000 IU 1 Vial is used to treat anemia in patients having chronic kidney diseases.

    • Chemotherapy associated anemia

      Epotin Injection 4000 IU 1 Vial is used to treat anemia associated with the use of chemotherapy medicines to treat certain specific types of cancer.

    • Anemia due to use of medicines

      Epotin Injection 4000 IU 1 Vial is used to treat anemia associated with the use of Zidovudine to treat HIV infection.

    • Anemia associated with surgery

      Epotin Injection 4000 IU 1 Vial is also used before and after certain surgeries where chances of significant blood loss is high. It reduces the dependency on blood transfusion process.

    Concerns

    Frequently asked questions

    • Onset of action

      The effect of this medicine can be observed after several days of administration.

    • Duration of Effect

      The time for which the effect of this medicine persists is subjected to variations depending on the intended use.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit forming tendencies were reported

    • Usage in pregnancy?

      Use of this medicine is not recommended for pregnant women unless absolutely necessary. All the potential benefits and risks should be considered before administering this medicine. Use of this medicine containing benzyl alcohol as an ingredient and use of multi-dose vial is not recommended for pregnant women.

    • Usage while breast-feeding?

      Use of this medicine is not recommended for women who are breastfeeding an infant unless absolutely necessary. The use of benzyl alcohol containing dosage forms or multi-dose vials are not recommended.

    When not to use?

    • Allergy

      This medicine is not recommended for use if you have a history of allergy to Epotin Injection 4000 IU 1 Vial or albumin or any other ingredient present in the dosage form.

    • Non-chemotherapy associated anemia in cancer patients

      This medicine is not recommended for use to treat anemia in cancer patients who are are not receiving any chemotherapy medication.

    • High blood pressure

      This medicine is not recommended for use in patients who have high blood pressure and are not taking any medicine to control it.

    • Pure red cell aplasia

      This medicine is not recommended for use if the patient has had a history of pure red cell aplasia after using this medicine or other medicines belonging to the Eryhtropoietin class of drugs.

    • Use of multi-dose vials

      Use of multi-dose vials of this medicine is not recommended for children or pregnant women. The risk of severe adverse effects are increasingly high in such cases.

    Warnings

    Warnings for special population
    • Pregnancy

      Use of this medicine is not recommended for pregnant women unless absolutely necessary. All the potential benefits and risks should be considered before administering this medicine. Use of this medicine containing benzyl alcohol as an ingredient and use of multi-dose vial is not recommended for pregnant women.

    • Breast-feeding

      Use of this medicine is not recommended for women who are breastfeeding an infant unless absolutely necessary. The use of benzyl alcohol containing dosage forms or multi-dose vials are not recommended.

    General Warnings
    • Not for immediate effect

      This medicine should not be used in cases where an immediate increase in red blood cell count is desired.

    • Ongoing cancer treatment

      This medicine is not recommended for use in patients who are being treated with biological or radiological medications. It is also not recommended for use in patients who are receiving myelosuppressive therapy for a curable form of cancer.

    • Surgery of heart and blood vessels

      This medicine is not recommended for use in patients who are about to have a surgery of the heart or blood vessels.

    • Autologous blood donation before surgery

      This medicine is not recommended for use in patients who are giving their own blood for transfusion before surgery.

    • Heart and blood vessel disorders

      This medicine should be used with caution since it can cause severe to fatal adverse effects especially in patients suffering from a pre-existing condition of the heart and blood vessels.

    • Seizures

      This medicine can cause seizures in patients suffering from a kidney disorder especially in the early stages of treatment. All such patients should be dosed carefully with appropriate monitoring.

    • Other ingredients

      This medicine may contain benzyl alcohol or albumin which increases the risk of certain adverse effects and hence should be carefully administered.

    • Multi-dose vials

      Use of multi-dose vials or vials containing benzyl alcohol is not recommended for small children.

    Dosage

    • Missed Dose

      Contact your doctor if you have missed a scheduled dose of this medicine and follow all the instructions given.

    • Overdose

      Contact your doctor immediately if an overdose is suspected.

    Interactions

    Interaction with Medicines
    • Ramipril
    • Cyclosporine moderate
    • Thalidomide severe
    Disease interactions
    • severe

      This medicine should be used with caution in patients with elevated blood pressure levels especially if it is uncontrolled. Your doctor will ensure that the blood pressure is under control before the use of Epotin Injection 4000 IU 1 Vial starts.

    • severe

      This medicine should be used with caution in patients suffering from seizure disorders as the risk of adverse effects are significantly high. You may require clinical monitoring at least in the early stages of treatment with Epotin Injection 4000 IU 1 Vial 

    • severe

      This medicine should be used with extreme caution in patients with blood clotting disorders since the risks of severe adverse effects are very high. Any disease of the heart and blood vessels should be reported to the doctor before treatment with Epotin Injection 4000 IU 1 Vial is initiated.

    • severe

      This medicine should be administered with caution in patients undergoing hemodialysis. Suitable dose adjustment and clinical monitoring is recommended while giving this medicine.

    Lab interactions

    General Instructions

    Take Epotin Injection 4000 IU 1 Vial alfa as instructed by the doctor and adhere to the dosage changes made in the course of treatment. It is advised to take this medication in the presence of a trained healthcare professional.

    Other details

    • Food timings: Information not available
    • Administration time: Information not available
    • Sleep inducing: Information not available

    References

    Additional Information>

    How to use Epotin Injection 4000 IU 1 Vial

    IV: Patients with CRF on dialysis: May be administered IV Bolus into the venous line after dialysis. Patients with CRF not on dialysis: May be administered IV or SC. Single-dose 1 mL vial contains no preservative. Use one dose per vial. Do not re-enter vial. Discard unused portions. Multidose 1 mL or 2 vial contains preservative. For minimal dilution, mix with bacteriostatic 0.9% sodium chloride, containing 20 mL of 0.9% sodium chloride and benzyl alcohol as the bacteriostatic agent. Dilutions of 1:10 and 1:20 (1 part epoetin: 19 parts sodium chloride) are stable for 18 hours at room temperature. Results showed no loss of epoetin alfa after a 1:20 dilution. 250 mcg/ mL albumin remaining after a 1:10 dilution of formulated epoetin alfa should be sufficient to prevent it from binding to commonly encountered containers. Prior to SC administration, preservative free solutions may be mixed with bacteriostatic NS containing benzyl alcohol 0.9% in a 1:1 ratio. Do not shake vial while preparing to avoid denaturing glycoprotein, inactivating drug.
    Compatibility: Stable in D10W with albumin 0.05%, D10W with albumin 0.1%. Incompatible with D10W with albumin 0.01%, D10W, NS.
    Stability: Vials should be stored at 2°C-8°C (36°F-46°F). Do not freeze or shake. Vials are stable for 2 weeks at room temperature. Single-dose 1 mL vial contains no preservatives. Use one dose per vial. Do not re-enter vial. Discard unused portions. Multidose 1 mL or 2 mL vial contains preservative. Store at 2°C-8°C after initial entry and between doses. Discard 21 days after initial entry.

    what are the adverse effects of Epotin Injection 4000 IU 1 Vial?

    Raised BP, headache, thrombosis, flu-like symptoms, seizures, skin reactions, rash, stroke, GI upset, palpebral oedema, musculoskeletal pain, cough, pyrexia. Rarely, pure red cell aplasia; withdraw and do not transfer to other erythropoietins. Inj site reactions.

    What happens if I miss a dose of Epotin Injection 4000 IU 1 Vial?

    Haemodialysis: Adults: Initially 50 IU/kg three times per wk by SC or IV inj following dialysis. Increase if necessary by 25 IU/kg three times per wk every 4 wk to achieve a Hb 10-12 gm/dl. Maintenance, 75-300 IU/kg per wk. Children: Initially 50 IU/kg three times per wk by IV inj following dialysis. Increase if necessary by 25 IU/kg three times per wk every 4 wk to achieve a Hb 9.5-11 gm/dl. Maintenance, under 10 kg, 75-150 IU/kg; 10-30 kg, 60-150 IU/kg; over 30 kg, 30-100 IU/kg. All three times per wk.
    Peritoneal dialysis: Adults: 50 IU/kg twice wkly by IV inj increase if necessary by 25 IU/kg twice wkly every 4 wk to achieve a Hb 10-12 gm/dl. Maintenance, 25-50 IU/kg per wk in two divided doses.
    Non-dialysis: Adults: Initially 50 IU/kg three times per wk by IV inj. Increase if necessary by 25 IU/kg three times per wk every 4 wk to achieve a Hb 10-12 gm/dl. Maintenance, 17-33 IU/kg per wk in three divided doses.
    Chemotherapy/autologous pre-donation and major elective orthopaedic surgery: Adults: See literature.

    One of the following licensed pharmacy from the nearest location will deliver Epotin Injection 4000 IU 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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