HOLOXAN 1gm Injection Vial

Frequently asked questions

• Onset of action

  The amount of time required for this medicine to show its action is not clinically established.

• Duration of Effect

  The amount of time for which this medicine remains active in the body is not clinically established.

• Safe with Alchohol?

  Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, seizures, etc . Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.

• Is it habit forming?

  No habit-forming tendencies were reported.

• Usage in pregnancy?

  This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

• Usage while breast-feeding?

  This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

• Allergy

  This medicine is not recommended for use in patients with a known allergy to HOLOXAN 1gm Injection Vial or any other inactive ingredients present along with it.

• Severe Kidney and/or Liver impairment

  This medicine is not recommended for use in patients with severe kidney and or liver diseases due to the increased risk of worsening of the patient's condition.

• Cystitis

  This medicine is not recommended for use in patients with cystitis (inflammation of the urinary bladder) or urinary flow obstruction due to the increased risk of worsening of the patient's condition.

• Pregnancy

  This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

• Breast-feeding

  This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

• Bonemarrow suppression

  This medicine may cause bone marrow suppression which in turn lowers the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary. The baseline of the blood cell count should be obtained before initiation of the treatment. Do not start the treatment if the counts are less.

• Infections

  The chances of infections are more in patients receiving this medicine. Hold the chemotherapy and start with broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

• Central Nervous System Toxicity

  This medicine is associated with many central nervous system toxicities such as confusion, hallucinations, blurred vision, psychotic behavior, extrapyramidal symptoms, seizures, and in some instances, coma, have been reported. Close monitoring of adverse reactions is recommended.

• Effects on kidney and urinary system

  This medicine is toxic to both kidneys and urinary system. Adverse reactions like altered kidney function, increased serum creatinine levels, altered electrolyte levels, etc has been reported with this medicine. Close monitoring of urine and kidney function is recommended. The treatment should be discontinued if the signs and symptoms of kidney injury appear.

• Effect on heart

  This medicine may increase the risk of toxic effects on the heart and could lead to congestive heart failure. The treatment should be monitored in patients with a history of heart disease.

• Liver disease

  This medicine should be used with caution in patients with mild to moderate liver diseases due to the increased risk of adverse effects. Regular monitoring of the liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

• Driving or Operating machinery

  Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

• Use in Children

  This medicine is not recommended for use in patients below 18 years of age unless prescribed by your physician. Your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. The blood cells count and kidney function should be assessed before starting the treatment. Any signs and symptoms of kidney, heart and urinary dysfunction should be reported to the doctor on priority.

• Usage does not depend on food timings
• To be taken as instructed by doctor
• May cause sleepiness

• webmd.com - Ifosfamide [Internet]. Available from: https://www.webmd.com/drugs/2/drug-8542/ifosfamide-intravenous/details [cited 1/9/2020].