LEUCOVORIN 50mg Injection 1s

LEUCOVORIN 50mg Injection 1s protects healthy cells from the harmful effects of anticancer drugs. It is an analog of folic acid and helps in the formation of red blood cells. It also increases the effect of certain anti-cancer medicines such as 5-fluorouracil.

Side effects

Major & minor side effects for LEUCOVORIN 50mg Injection 1s

• Severe skin rash and hives severe
• Swelling of the face, arms, hands, lower legs, or feet severe
• Difficulty in breathing severe
• Difficulty in swallowing severesevere
• Fainting
• Fever severe
• Convulsions (seizures) severe
• Agitation and anxiety
• Indigestion
• Difficulty in falling asleep
• Peeling and blistering of skin severe
• Constipation
• Unusual tiredness or weakness

Uses of LEUCOVORIN 50mg Injection 1s

What is it prescribed for?

• Methotrexate rescue

  This medicine is used to reduce the toxicity caused due to the administration of methotrexate. It is also used to counteract the effects of an impaired methotrexate elimination or accidental overdosage.

• Folic acid antagonist overdose

  This medicine is also used to replenish folic acid in the body and reduce the toxicity caused due to the administration of folic acid antagonists such as aminopterin, pyrimethamine, trimethoprim, triamterene, etc. It is also used to counteract the toxic effects caused due to an accidental overdose of these medicines.

• Megaloblastic Anemia

  This medicine is used to treat megaloblastic anemia, a type of anemia with a lower than the normal number of red blood cells, caused by a deficiency of folic acid due to malnourishment, liver disease, pregnancy, or a reduced ability to absorb folic acid from the diet.

• Colorectal Cancer

  This medicine is used along with 5-Fluorouracil to prolong survival of the patients suffering from advanced colorectal cancer.This medicine is used along with 5-Fluorouracil to prolong survival of the patients suffering from advanced colorectal cancer.

When not to use?

• Other medicines

  This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

• Use in elderly

  This medicine should be used with caution in the elderly patients since the risk of adverse effects is significantly high. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition.

• Seizure disorders

  This medicine should be used with caution in patients with an active seizure disorder since it may worsen the patient's condition. This risk is especially higher if higher doses of this medicine are used. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition.

• Serious allergic reactions

  Use of this medicine may cause severe or life-threatening allergic reactions in some patients. This risk is especially higher when this medicine is used as a part of a combination therapy. Report any unusual symptoms such as increased sweating, difficulty breathing, itching, chills, etc. to your doctor immediately. Appropriate corrective measures and replacement with a suitable alternative may be necessary based on the patient's condition.

• Form of medicine and dosing schedule

  The dosing schedule and form of administration are likely to vary based on the condition being treated and co-administration of other medicines along with LEUCOVORIN 50mg Injection 1s . Do not change the dose or schedule of uptake of this medicine without consulting your doctor.

• Gastrointestinal toxicities

  The combination therapy of 5-fluorouracil and this medicine should be used with caution due to the increased risk of gastrointestinal toxicities. These toxicities may include swelling of the gastrointestinal tract walls and diarrhea. This risk is especially higher if the combination therapy is used for a prolonged period of time. Therapy should not be initiated or continued in such patients unless symptoms of toxicity are completely resolved.

Oral forms: Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Injectable forms: This medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting. Follow all the instructions given by your doctor. Report to the doctor if you have a known allergy to this medicine. Report all your current medicines, including any herbs and supplements, and your medical conditions to the doctor before receiving treatment with this medicine.

• Usage does not depend on food timings
• To be taken as instructed by doctor
• May cause sleepiness

• practo.com - Leucovorin [Internet]. Available from: https://www.practo.com/medicine-info/leucovorin-2176-api [cited 28 september 2019]. 21 Sep 2018