Multiparin Injection 5000 IU 10 Vial

 5,500.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 5000 IU
Drug Form : Injection
Pack Size : 10 Vial
Does this requires a prescription ?Yes

Multiparin Injection contains Heparin | belongs to Anticoagulant

SKU: pg_15304_21298 Category:

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    How it works

    Multiparin Injection 5000 IU 10 Vial works by decreasing the clotting ability of the blood.

    Side effects

    Major & minor side effects for Multiparin Injection 5000 IU 10 Vial

    • Abdominal and stomach pain
    • Back pain
    • Bleeding gums
    • Easy Bruising and bleeding
    • Severe and continuing headaches
    • Constipation
    • Bloody stool
    • Chest pain and discomfort rare
    • Injection site Thrombophlebitis rare
    • Nausea or Vomiting
    • Skin rash and peeling rare
    • Change in vision rare
    • Puffing or swelling of eyelids
    • Ulcers at the injection site rare
    • Osteoporosis severe
    • Increased liver enzyme levels severe

    Uses of Multiparin Injection 5000 IU 10 Vial

    What is it prescribed for?

    • Deep Vein Thrombosis

      This medicine is used for the prevention and treatment of blood clot formation in a deep vein, most commonly in the legs.

    • Thromboembolism in Atrial Fibrillation

      This medicine is used for the treatment and prevention of the formation of obstructive clots (Thromboembolism) in blood vessels, associated with atrial fibrillation.

    • Pulmonary Embolism

      This medicine is used for the treatment and prevention of pulmonary embolism, a condition where one or more arteries in the lungs become blocked by a clot. The blood clot is normally formed elsewhere and migrates to the lung via blood.

    • Disseminated intravascular coagulation

      This medicine is used for the treatment of both short and long-term formation of blood clots in the small blood vessels throughout the body which may cause damage to multiple organs.

    • Venous thromboembolic events

      This medicine is used to treat and prevent the formation of blood clots in veins, which could potentially break loose and migrate to other locations, causing further complications.

    • Prevention of clots during surgeries

      This medicine is used to prevent clot formation during complex surgeries of the heart and the blood vessels. It is also used for the prevention of reocclusion of blood vessels in the heart after correctional surgery is performed.

    • Blood transfusion

      This medicine is used for the prevention of clot formation during the blood transfusion process.

    • Maintenance of patency of implanted intravenous devices

      This medicine is used in small quantities to prevent the formation of blood clots in devices/catheters that are left in the veins for a period of time (maintenance of patency).

    Concerns

    Frequently asked questions

    • Onset of action

      The effect of this medicine can be observed immediately after intravenous administration. Upon subcutaneous administration, the effect can be observed within 20-60 minutes.

    • Duration of Effect

      The time duration for which this medicine remains effective is subject to vary based on the intended use, dose strength, and route of administration.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Usage in pregnancy?

      This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

    • Usage while breast-feeding?

      This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

    When not to use?

    • Allergy

      This medicine is not recommended for use in patients with a known allergy to Multiparin Injection 5000 IU 10 Vial or any other inactive ingredient present along with it.

    • Uncontrolled active bleeding

      This medicine is not recommended for use in patients having uncontrolled active bleeding except when it is associated with Disseminated intravascular coagulation.

    • Inability to perform coagulation tests

      This medicine is not recommended for use in patients who cannot undergo coagulation tests at appropriate intervals. This is generally applicable for patients receiving full dose therapy, not for those on a fixed low-dose therapy.

    • Thrombocytopenia

      This medicine is not recommended for use in patients with a known history of thrombocytopenia associated with the use of Multiparin Injection 5000 IU 10 Vial .

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

    • Breast-feeding

      This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

    General Warnings
    • Hemorrhage and risk factors

      Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.

    • Thrombocytopenia

      Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

    • Use in elderly

      This medicine should be used with extreme caution in the elderly population since the risk of adverse effects is significantly high. Appropriate dose adjustments and frequent clinical monitoring are advised for such patients to safely use this medicine.

    • Benzyl alcohol as preservative

      Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, and pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.

    • Liver/kidney disease

      This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

    • Hyperkalemia

      Use of this medicine may cause an increase in blood potassium levels (hyperkalemia) and associated complications. Close monitoring of potassium levels may be necessary based on the clinical condition.

    • Osteoporosis

      Use of this medicine in high doses for a prolonged duration may cause osteoporosis and associated complications.

    • Other medicines

      This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.

    • Occurrence of side effects

      It is possible that you may experience certain side effects after the use of this medicine has been stopped. Report any instances of unusual symptoms to the doctor immediately.

    • Smoking and use of tobacco products

      Inform the doctor about your smoking habits or use of tobacco in any form before treatment with this medicine is initiated. Use of tobacco products may decrease the effectiveness of this medicine.

    • Injection incompatibility

      The intravenous form of this medicine should not be mixed with certain diluents and medicines due to incompatibility. Caution should be exercised while picking the diluent and other medicines at the time of administration.

    Dosage

    • Missed Dose

      This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.

    • Overdose

      Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms of an overdose may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.

    Interactions

    Interaction with Medicines
    • Enoxaparin severe
    • Escitalopram moderate
    • Glimepiride moderate
    • Mifepristone severe
    • Telmisartan moderate
    • Warfarin severe
    • Apixaban severe
    • Ketorolac severe
    • NSAIDs moderate
    • Alteplase severe
    • Bivalirudin severe
    • Dabigatran severe
    • Streptokinase severe
    • Ubiquinone/Vitamin E moderate
    • Ginseng moderate
    Disease interactions
    • severe

      Use of this medicine is not recommended in patients with an active peptic ulcer disease due to the increased risk of severe internal bleeding and hemorrhage which may be fatal.

    • severe

      Use of this medicine is not recommended in patients with an active bleeding disorder due to the increased risk of excessive bleeding which may be fatal. However, this medicine can be used for treating patients diagnosed with disseminated intravascular coagulation.

    • severe

      This medicine should be used with extreme caution in patients having a kidney disease or impairment of normal renal function due to the increased risk of excessive bleeding. Appropriate dose adjustments and close monitoring of kidney function are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

    • severe

      This medicine should be used with extreme caution in patients with Thrombocytopenia due to the increased risk of worsening of the patient's condition. Appropriate tests including blood platelet counts must be done before starting therapy and at regular intervals during therapy to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition.

    • moderate

      This medicine should be used with caution due to the increased risk of hyperkalemia (increased serum potassium levels) which may cause severe side effects such as an irregular heart rhythm, muscle paralysis, etc. This risk is especially higher in elderly patients with heart diseases, kidney diseases, or diabetes mellitus. Appropriate tests must be conducted to determine the potassium levels before and during treatment with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition.

    Food interactions
    • This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction. This medicine should be used with caution with ginger/garlic due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.

    General Instructions

    Administer Multiparin Injection 5000 IU 10 Vial 5000 IU Injection exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.

    Other details

    • Usage does not depend on food timings
    • To be taken as instructed by doctor
    • Does not cause sleepiness

    References

    Additional Information>

    How to use Multiparin Injection 5000 IU 10 Vial

    IV: Continuous inf: Infuse via infusion pump. Heparin lock: Inject via inj cap using positive pressure flushing technique. Heparin lock flush soln is intended only to maintain patency of IV devices & is not to be used for anticoagulant therapy. SC: Administer into anterior abdominal wall, above the iliac crest & 5 cm or more away from the umbilicus. To minimize tissue trauma, lift adipose tissue away from deep tissues. Do not move needle while injecting drug & do not massage inj site before or after inj. Apply gentle pressure to the site after withdrawing needle. Use alternate inj sites.
    Reconstitution: Standard diluent: 25000 units/500 mL D5W (premixed). Minimum volume: 250 mL D5W. For continuous inf, invert container at least 6 times to prevent drug from pooling.
    Compatibility: Stable in dextran 6% in dextrose, dextran 6% in NS, D5LR, D5¼NS, D5½NS, D25W, fat emulsion 10%, ½NS, NS.
    Y-site administration:
    Drug to Drug IV Compatibility: Acyclovir, aztreonam, bumetanide, cephazolin, cefepime, ceftriaxone, cimetidine, dexamethasone, digoxin, dopamine, enalapril, epinephrine, famotidine, fluconazole, furosemide, imipenem, insulin regular, lansoprazole, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, metronidazole, midazolam, milrinone, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, piperacillin/tazobactam, propofol, ranitidine, vasopressin, vecuronium.
    Drug to Drug IV Incompatibility: Alteplase, amikacin, amiodarone, amphotericin B, atracurium, chlorpromazine, ciprofloxacin, cisatracurium, clarithromycin, cytarabine, daunorubicin, diazepam, dobutamine, doxorubicin, doxycycline, droperidol, ergotamine, erythromycin lactobionate, fentanyl, filgrastim, gatifloxacin, gentamicin, haloperidol, idarubicin, isosorbide dinitrate, kanamycin, levofloxacin, pentazocine, phenytoin, promethazine, streptomycin, tobramycin, vancomycin, warfarin.

    what are the adverse effects of Multiparin Injection 5000 IU 10 Vial?

    Bleeding complications, transient alopecia, thrombocytopenia; osteoporosis (long-term therapy), febrile or allergic reactions, hypoaldosteronism, local reaction at injection site.

    What happens if I miss a dose of Multiparin Injection 5000 IU 10 Vial?

    Adults: Based on 68 kg: LD: 5000 units IV, then 10,000-20,000 units SC. Maintenance: 8000-10,000 units every 8 hr or 15,000-20,000 units every 12 hr. Intermittent IV Injection: LD: 10,000 units. Maintenance: 5000-10,000 units every 4-6 hr. IV Infusion: LD: 5,000 units. Maintenance: 20,000-40,000 units/day.
    Treatment of pulmonary embolism, unstable angina & acute peripheral arterial occlusion: By IV, loading dose of 5000 units or 75 units/kg (10000 units in severe pulmonary embolism), followed by continuous IV inf of 18 units/kg/hr.
    Treatment of deep-vein thrombosis: By IV inj, loading dose of 5000 units or 75 units/kg, followed by continuous IV inf of 18 units/kg/hr or by SC of 15000 units every 12 hrs.
    Thromboprophylaxis in medical patients by SC inj: 5000 units every 8-12 hrs.
    Thromboprophylaxis in surgical patients by SC inj: 5000 units 2 hrs before surgery, then every 8-12 hrs.
    Thromboprophylaxis during pregnancy by SC inj: 5000-10000 units every 12 hrs.
    Haemodialysis by IV inj: Initially 1000-5000 units, followed by continuous IV inf of 250-1000 units/hr.
    Children: Some preparation are licensed for use in children. Maintenance of neonatal umbilical arterial catheter: IV infusion. Neonate, 0.5 units/hr. Treatment of thrombotic episodes: IV. Neonate, initially 75 units/kg (50 units/kg if under 35 wk corrected gestational age) by IV injection, then by continuous IV infusion 25 units/kg/hr, adjusted according to APTT; 1 mth-1 yr, initially 75 units/kg by IV injection, then by continuous IV infusion 25 units/kg/hr, adjusted according to APTT; 1-18 yr, initially 75 units/kg by IV injection, then by continuous IV infusion 20 units/kg/hr, adjusted according to APTT. By SC injection, 1 mth-18 yr 250 units/kg twice daily, adjusted according to APTT.
    Prophylaxis of thrombotic episodes: SC injection. 1 mth-18 yr, 100 units/kg (max 5000 units) twice daily, adjusted according to APTT.
    Prevention of clotting in extracorporeal circuits: Consult product literature.
    Maintenance of cardiac shunts and critical stents: Consult product literature.

    One of the following licensed pharmacy from the nearest location will deliver Multiparin Injection 5000 IU 10 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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