Nestigen Injection 0.5 mg 5 Ampx1 mL

 57.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 0.5 mg
Drug Form : Injection
Pack Size : 5 Ampx1 mL

Nestigen Injection contains Neostigmine | belongs to Anticholinesterase

SKU: pg_15921_22071 Categories: ,

Alternate brands of Nestigen Injection 0.5 mg 5 Ampx1 mL

Brand Name Price Savings
Stigma Injection 2.5 mg 10 Ampx5 mL  624.00 You will pay -567 more
Nestigen Injection 2.5 mg 10 Ampx1 mL  370.00 You will pay -313 more
Nestigen Injection 2.5 mg 5 Ampx1 mL  195.00 You will pay -138 more
Nestigen Injection 0.5 mg 100 Ampx1 mL  1,000.00 You will pay -943 more
Neostig Injection 2.5 mg 5 Ampx5 mL  209.00 You will pay -152 more
List of alternate brands

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How it works

Nestigen Injection 0.5 mg 5 Ampx1 mL works by blocking the action of acetylcholinesterase and therefore increases the levels of acetylcholine.[2]

Side effects

Major & minor side effects for Nestigen Injection 0.5 mg 5 Ampx1 mL

  • Twitches of the muscle visible under the skin
  • Loss of vision or blurred vision
  • Chest pain or discomfort
  • Fast, pounding, or irregular heartbeat
  • Lightheadedness, dizziness, or fainting
  • Constipation
  • Nausea and vomiting
  • Skin rash
  • Drowsiness
  • Increased watering of the mouth

Uses of Nestigen Injection 0.5 mg 5 Ampx1 mL

What is it prescribed for?

  • Myasthenia gravis

    This medicine is used to treat myasthenia gravis, a neuromuscular disorder where the muscles become weak and tire easily.

  • Urinary retention

    This medicine is used for the prevention and treatment of urinary retention. It is also used to treat and prevent urinary retention after surgery

  • Reversal of neuromuscular blockade

    This medicine is used to reverse the neuromuscular blocking effects of muscle relaxants.

  • Paralytic ileus

    This medicine is used to treat paralytic ileus, a condition where the normal movements of the intestine are absent.

Concerns

Frequently asked questions

  • Onset of action

    Parenteral Form: The effect of this medicine can be observed within 1-20 minutes on an intravenous administration and within 20-30 minutes on an intramuscular administration of the dose. Oral Form: The amount of time required for this medicine to show its action is not clinically established.

  • Duration of Effect

    Parenteral Form: The effect of this medicine lasts for an average duration of 1-2 hours after an intravenous administration and lasts for an average duration of 2.5-4 hours after an intramuscular administration of the dose. Oral Form: The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving/taking this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving/taking this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use if you have a known allergy to Nestigen Injection 0.5 mg 5 Ampx1 mL or previous history of reaction to bromides.

  • Peritonitis

    This medicine is not recommended for use in patients with a known history of peritonitis (inflammation of the thin layer of the abdominal wall) due to the increased risk of worsening of the patient's condition.

  • Urinary tract obstruction

    This medicine is not recommended for use in patients with urinary tract obstruction (blockage of the outflow of urine) due to the increased risk of worsening of the patient's condition.

  • Mechanical Gastrointestinal Obstruction

    This medicine is not recommended for use in patients with gastrointestinal tract obstruction due to the increased risk of worsening of the patient's condition.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving/taking this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving/taking this medicine.

General Warnings
  • Bradycardia

    This medicine should be used with extreme caution in patients with bradycardia (low heart rate) due to the risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative should be considered based on the clinical condition.

  • Driving and operating machinery

    This medicine may cause dizziness, fainting, drowsiness, or visual disturbances in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

  • Hyperthyroidism

    This medicine should be used with caution in patients with hyperthyroidism (a condition where the thyroid gland produces excess thyroid hormones) since it may worsen the patients' condition. Close monitoring of thyroid function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

  • Peptic ulcer

    This medicine should be used with extreme caution in patients with a known history of peptic ulcer disease since it may worsen the patient's condition. Report any unusual side effects to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Dosage

  • Missed Dose

    Parenteral Form: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. Oral Form: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

  • Overdose

    Parenteral Form: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected. Oral Form: Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Deflazacort moderate
  • Propranolol moderate
  • Tramadol severe
  • Atropine moderate
  • Bupropion severe
  • Budesonide moderate
  • Budesonide moderate
Disease interactions
  • severe

    This medicine should be used with caution in patients with a known history of respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc. since it may worsen the patient's condition. Close monitoring of respiratory function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

  • severe

    This medicine should be used with extreme caution in patients with coronary artery disease due to the risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative should be considered based on the clinical condition.

  • severe

    This medicine should be used with extreme caution in patients with parkinsonism due to the risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative should be considered based on the clinical condition.

  • severe

    This medicine should be used with extreme caution in patients with a known history of peptic ulcer disease since it may worsen the patient's condition. Report any unusual side effects to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

  • severe

    This medicine should be used with caution in patients with a known history of seizures since it may worsen the patients' condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

  • moderate

    This medicine should be used with caution in patients with hyperthyroidism (a condition where the thyroid gland produces excess thyroid hormones) since it may worsen the patients' condition. Close monitoring of thyroid function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

General Instructions

Parenteral Form: This medicine is usually administered in the clinical setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Oral form: Take this medicine with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor.

References

Additional Information>

How to use Nestigen Injection 0.5 mg 5 Ampx1 mL

Administered by IM, SC, or slowly IV.
Stability: Stored at room temperature and protect from light, freezing and temperatures of 40 degree centigrade or more.

what are the adverse effects of Nestigen Injection 0.5 mg 5 Ampx1 mL?

Nausea, vomiting, increased salivation, diarrhoea and abdominal cramp.

What happens if I miss a dose of Nestigen Injection 0.5 mg 5 Ampx1 mL?

Adults: Paralytic ileus, post-operative distension: 0.5-2.5 mg IM or SC as required.
Post-operative urinary retention: 0.5- 2.5 mg IM or SC as required.
Myasthaenia gravis, diagnosis: Including Elderly, IM: 0.02 mg/kg as a single dose.
Myasthaenia gravis, treatment: Including Elderly, IM/IV/SC: 0.5-2.5 mg Every 1-3 hr. Max: 10 mg/24 hr.
Reversal of non-depolarizing neuromuscular blockade after surgery in conjunction with atropine: Including Elderly: IV: 0.5-2.5 mg.
Bladder atony: Including Elderly, IM/SC: Prevention: 0.25 mg every 4-6 hr for 2-3 days. Treatment: 0.5-1 mg every 3 hr for 5 doses after bladder has emptied.
Children: Treatment of myasthaenia gravis: Oral (as neostigmine bromide): Neonate, initially 1-2 mg, then 1-5 mg every 4 hr, give 30 minutes before feeds; Up to 6 yr, initially 7.5 mg repeated at suitable intervals throughout the day, total daily dose 15-90 mg; 6-12 yr, initially 15 mg repeated at suitable intervals throughout the day, total daily dose 15-90 mg; 12-18 yr, initially 15-30 mg repeated at suitable intervals throughout the day, total daily dose 75-300 mg (most can tolerate is 180 mg daily). SC or IM injection (as neostigmine metilsulphate): Neonate, 150 mcg/kg every 6-8 hr, 30 minutes before feeds, increased to max 300 mcg/kg every 4 hr, if necessary; 1 mth-12 yr, 200-500 mcg repeated at suitable intervals throughout the day; 12-18 yr, 1-2.5 mg repeated at suitable intervals throughout the day.
Reversal of non-depolarising muscle block: IV injection over 1 minute: Neonate, 50 mcg/kg, after or with glycopyrronium or atropine; a further dose of 25 mcg/kg may be required; 1 mth-12 yr, 50 mcg/kg (max 2.5 mg) after or with glycopyrronium or atropine; a further dose of 25 mcg/kg may be required; 12-18 yr, 50 mcg/kg (max 2.5 mg) after or with glycopyrronium or atropine; a further dose of 25 mcg/kg (max 2.5 mg) may be required.

One of the following licensed pharmacy from the nearest location will deliver Nestigen Injection 0.5 mg 5 Ampx1 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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