Syntra Injection IV 0.05 mg 10 Ampx5 mL

 210.00

Syntra Injection IV contains Fentanyl | belongs to Opioid analgesic

SKU: pg_22098_30651 Categories: ,
Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 0.05 mg
Drug Form : Injection IV
Pack Size : 10 Ampx5 mL

Alternate brands of Syntra Injection IV 0.05 mg 10 Ampx5 mL

Brand Name Price Savings
Fentra Injection 0.05 mg 10 Ampx5 mL  225.78 You will pay -15.78 more
List of alternate brands

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How it works

Syntra Injection IV 0.05 mg 10 Ampx5 mL works by changing the way the brain and nervous system respond to pain.

Side effects

Major & minor side effects for Syntra Injection IV 0.05 mg 10 Ampx5 mL

  • Blurred vision
  • Chest pain
  • Confusion
  • Dizziness
  • Irregular heartbeat
  • Lightheadedness
  • Nausea or Vomiting
  • Sudden swelling of hands, feet and ankles
  • Change in mood
  • Loss of appetite

Uses of Syntra Injection IV 0.05 mg 10 Ampx5 mL

What is it prescribed for?

  • Breakthrough Cancer Pain

    This medicine is used in treating the sudden episodes of increased pain in patients suffering from cancer which is known to be stable and persistent otherwise.

  • Anesthesia

    The medicine can be administered as an anesthetic medication during or before major or minor surgical procedures.

  • Chronic pain

    The medicine is used for the treatment of patients suffering from pain since a long time and has developed tolerance to non-opioids even in high doses.

  • Regional anesthesia

    This medicine can be used as an additive with general anesthetic to produce sedation during surgical procedures.

Concerns

Frequently asked questions

  • Onset of action

    The amount of time taken by this medicine to show its effect is subject to vary based on the individual, strength and form of administration.

  • Duration of Effect

    The amount of time for which this medicine remains effective is subject to vary based on the individual, strength and form of administration.

  • Safe with Alchohol?

    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of adverse effects such as dizziness, drowsiness, lightheadedness, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.

  • Is it habit forming?

    Has a high potential for abuse. Abuse may lead to severe psychological or physical dependence.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to Syntra Injection IV 0.05 mg 10 Ampx5 mL or any other inactive ingredients present in the formulation.

  • Respiratory depression

    This medicine is not recommended for use in patients with respiratory depression due to the increased risk of worsening of the patient's condition.

  • Gastrointestinal obstruction

    This medicine is not recommended for use in patients with gastrointestinal obstruction including paralytic ileus due to the increased risk of worsening of the patient's condition.

  • Monoamine oxidase inhibitors (MAOI)

    This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

General Warnings
  • Seizures

    This medicine should be used with caution in patients with a known history of seizures due to the increased risk of recurrent seizures. Close monitoring, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Kidney Disease

    This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Liver Disease

    This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Driving or Operating machinery

    Use of this medicine may cause blurred vision or dizziness. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

  • Drug Dependence

    This medicine has the potential to cause drug dependence and abuse. This risk is especially higher if the medicine is used for a prolonged period of time. Patients should be monitored closely for any change in mood and behavior during treatment with this medicine. Abrupt discontinuation is not recommended since it may cause withdrawal symptoms.

Dosage

  • Missed Dose

    Oral (Sub-Lingual): Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose. Injection: Since this medicine is usually administered by a qualified healthcare professional before and during a surgical procedure in the clinical/hospital setting, the likelihood of a missed dose is very low. Transdermal: Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

  • Overdose

    Oral & Transdermal: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Interactions

Interaction with Medicines
  • Clonazepam severe
  • Bupropion severe
  • Amitriptyline severe
  • Chlordiazepoxide severe
  • Diazepam severe
Disease interactions
  • severe

    This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • severe

    This medicine should be used with extreme caution in patients with hypotension due to the increased risk of orthostatic hypotension. Regular monitoring of blood pressure, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • severe

    This medicine should be used with extreme caution in patients suffering from intracranial hypertension due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • moderate

    This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

General Instructions

Oral (Sub-Lingual) & Transdermal: Follow all the instructions given by your doctor and administer this medicine exactly as advised. Do not administer in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Injection: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • Causes sleepiness

References

Additional Information>

How to use Syntra Injection IV 0.05 mg 10 Ampx5 mL

Administered by IM or IV injection.
Compatibility: Stable in dextrose 5%, NaCl 0.9%.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, calcium gluconate, cephazolin, ceftriaxone, cimetidine, cisatracurium, dexamethasone, digoxin, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fluconazole, furosemide, gentamicin, heparin, hydrocortisone, hydromorphone, imipenem, insulin regular, ketorolac, labetalol, lansoprazole, levofloxacin, linezolid, lorazepam, magnesium sulphate, methylprednisolone, metoclopramide, midazolam, milrinone, morphine, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, piperacillin/tazobactam, propofol, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
Drug to Drug IV Incompatibility: Azithromycin, pantoprazole.
In syringe: Incompatible with pentobarbital.
When admixed: Incompatible with fluorouracil, methohexital, pentobarbital, thiopental.
Stability: Store at controlled room temperature and protect from light.

what are the adverse effects of Syntra Injection IV 0.05 mg 10 Ampx5 mL?

Hypotension, somnolence, dizziness, hallucinations, pruritus, sweating, bradycardia, GI upset, urinary retention, headache, confusion, asthaenia, dyspnoea, respiratory depression. Tolerance and dependence. Rash, erythema and itching.

What happens if I miss a dose of Syntra Injection IV 0.05 mg 10 Ampx5 mL?

Adults: PATCHES: Apply to dry, non-irritated, non-irradiated, non-hairy skin on torso or upper arm, removing after 72 hr and apply new patch on a different area (avoid using the same area for several days). Patients who have not previously received a strong opioid analgesic, initial dose, one 25 mcg/hr patch replaced after 72 hr. Patients who have received a strong opioid analgesic, initial dose based on previous 24-hr opioid requirement (oral morphine sulphate 90 mg over 24 hr is approximately equivalent to one 25 mcg/hr patch).
Adults: INJECTION: With spontaneous respiration: By slow IV injection, initially 50-100 mcg (max 200 mcg on specialist advice), then 25-50 mcg as required. By IV infusion, 3-4.8 mcg/kg/hr adjusted according to response. With assisted ventilation: By slow IV injection, initially 0.3-3.5 mg, then 100-200 mcg as required. By IV infusion, initially 10 mcg/kg over 10 min then 6 mcg/kg/hr adjusted according to response; may require up to 180 mcg/kg/hr during cardiac surgery.
Adults: ORAL: Breakthrough pain in patients receiving opioid therapy for chronic cancer pain: Initially 100 mcg repeated if necessary after 15-30 min; adjust dose according to response (consult product literature) no more than 2 dose units, 15-30 min apart, for each pain episode; max 800 mcg per episode of breakthrough pain.
Children: Not recommended for children under 2 yr; infusion not recommended for children under 12 yr.
Spontaneous respiration: Analgesia and enhancement of anaesthesia during operation: IV injection over at least 30 sec: 1 mth-12 yr, initially 1-3 mcg/kg, then 1 mcg/kg as required; 12-18 yr, initially 50-100 mcg, max 200 mcg, then 25-50 mcg as required.
Assisted ventilation: Analgesia and enhancement of anaesthesia during operation: IV injection over at least 30 sec: Neonate, initially 1-5 mcg/kg, then 1-3 mcg/kg as required; 1 mth-12 yr, initially 1-5 mcg/kg, then 1-3 mcg/kg as required; 12-18 yr, initially 1-5 mcg/kg, then 50-200 mcg as required.
Assisted ventilation: Analgesia and respiratory depression in intensive care: Neonate, initially by IV injection 1-5 mcg/kg, then by IV infusion, 1.5 mcg/kg/hr adjusted according to response; 1 mth-18 yr, initially by IV injection 1-5 mcg/kg, then by IV infusion, 1-6 mcg/kg/hr adjusted according to response.
Severe chronic pain, breakthrough pain and premedication analgesia: See product literature. PATCHES: For use in combination with or during use with opioid analgesic consult product literatures. Child aged 16-18 yr, not currently treated with strong opioid analgesic, one ‘12’ or ‘25 mcg/hr’ patch replaced after 72 hr.
Spontaneous respiration: Analgesia and enhancement of anaesthesia during operation: IV injection over at least 30 sec: 1 mth-12 yr, initially 1-3 mcg/kg, then 1 mcg/kg as required; 12-18 yr, initially 50-100 mcg, max 200 mcg, then 25-50 mcg as required.
Assisted ventilation: Analgesia and enhancement of anaesthesia during operation: IV injection over at least 30 sec: Neonate, initially 1-5 mcg/kg, then 1-3 mcg/kg as required; 1 mth-12 yr, initially 1-5 mcg/kg, then 1-3 mcg/kg as required; 12-18 yr, initially 1-5 mcg/kg, then 50-200 mcg as required.
Assisted ventilation: Analgesia and respiratory depression in intensive care: Neonate, initially by IV injection 1-5 mcg/kg, then by IV infusion, 1.5 mcg/kg/hr adjusted according to response; 1 mth-18 yr, initially by IV injection 1-5 mcg/kg, then by IV infusion, 1-6 mcg/kg/hr adjusted according to response.

One of the following licensed pharmacy from the nearest location will deliver Syntra Injection IV 0.05 mg 10 Ampx5 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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