₨ 2,630.00
MBBS
Uperio tablet 100 mg 28’s
- Does this requires a prescription ? Yes
- Generic Name: Sacubitril and Valsartan
- Manufactured by : Novartis
- Drug Strength : 100 mg
- Drug Form : Tablet
- Pack Size : 28s
- Product SKU : pu_pg_23495_32505
Uperio tablet contains Sacubitril and Valsartan | belongs to Angiotensin II antagonist
Alternate brands of Uperio tablet 100 mg 28’s
| Brand Name | Price | Savings |
|---|---|---|
| Uperio tablet 200 mg 28’s | ₨ 2,940.00 | You will pay -310 more |
How it works
Uperio tablet 100 mg 28’s by inhibiting an enzyme neprilysin that degrades certain substances necessary for lowering the blood pressure in the body. Uperio tablet 100 mg 28’s works by preventing the narrowing of blood vessels and promoting smooth blood flow.
Side effects
Major & minor side effects for Uperio tablet 100 mg 28’s
- Dizziness severe
- Stomach pain severe
- Nausea
- Diarrhea
- Decreased blood pressure severe
- Headache severe
- Fainting severe
- Cough
- Weight gain
- Increased thirst
- Unusual tiredness and weakness severe
Uses of Uperio tablet 100 mg 28’s
What is it prescribed for?
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Chronic heart failure
This medicine is used for the prevention of cardiac symptoms in patients suffering from chronic heart failure and reduced ejection fraction. It reduces the risk of hospitalization and death associated with heart failure in such patients.
Concerns
Frequently asked questions
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Onset of action
The amount of time required for this medicine to show its action is not clinically established.
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Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit-forming tendency has been reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Uperio tablet 100 mg 28’s, or any other inactive ingredients present in the formulation.
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Aliskiren
Coadministration of aliskiren and this combination medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.
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Angioedema
This medicine is not recommended for use in patients with a known history of angioedema caused due to hereditary causes, or an unknown cause or associated with the use of medicines like an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB). It is recommended not to take ACE inhibitors within 36 hours of switching to or from this combination medicine.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
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Renal artery stenosis
This medicine should be used with caution in patients with renal artery stenosis due to the increased risk of severe adverse effects. Close monitoring of blood urea and serum creatinine levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
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Hyperkalemia
This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine.
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Use in children
This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.
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Driving and operating machines
This medicine may cause dizziness or fatigue in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
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Angioedema
This medicine is not recommended for use in patients with a known history of angioedema due to the increased risk of worsening of the patient's condition. Report any symptoms such as swelling of the face or lips, difficulty swallowing, or difficulty breathing to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.
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Diabetes
This medicine should be used with caution in patients suffering from diabetes due to the increased risk of altered blood sugar levels. Close monitoring of blood sugar levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Dosage
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Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
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Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
Interactions
Interaction with Medicines- Insulin moderate
- Dexamethasone moderate
- Angiotensin converting enzyme inhibitors (ACEI's) severe
- Nonsteroidal anti-inflammatory medicines moderate
- Spironolactone severe
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moderate
This medicine should be used with caution in patients with kidney or liver impairment, especially in severe conditions. The patients with mild to moderate liver impairment do not require any dose adjustments. In the same way, dosage adjustments are not required in patients with kidney impairment unless if the patients are volume depleted.
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severe
This medicine should be used with extreme caution in patients with low blood pressure, decreased sodium levels or volume depletion. Sodium or volume depletion should be corrected before starting treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
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It is advised to avoid potassium containing foods and supplements while taking this medicine due to the increased risk of weakness, confusion, irregular heartbeat, etc. Report any unusual symptoms to the doctor immediately. Your dietitian/doctor may suggest appropriate changes in your diet based on your clinical condition.
General Instructions
Take this medicine exactly as advised by your doctor. Do not take in larger or smaller amounts than prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Other details
- Can be taken with or without food, as advised by your doctor
- To be taken as instructed by doctor
- May cause sleepiness
References
- practo - Sacubitril Valsartan [Internet]. Available from: https://www.practo.com/medicine-info/vymada-50-tablet-54074 [cited 1/12/2021]. 2019
what are the adverse effects of Uperio tablet 100 mg 28’s?
Anaemia, gastritis, diarrhoea, nausea, vertigo, hypoglycaemia, hypokalaemia.
What happens if I miss a dose of Uperio tablet 100 mg 28’s?
In patients not currently taking an ACE inhibitor or angiotensin II receptor antagonist, or stabilized on low doses of either of these agents: Initially 26/24 mg twice daily for 3-4 wks, increased if tolerated to 51/49 mg twice daily for 3-4 wks, then increased if tolerated to 103/97 mg twice daily.
In patients currently stabilized on an ACE inhibitor or angiotensin II receptor antagonist: Initially 51/49 mg twice daily for 2-4 wks, increased if tolerated to 103/97 mg twice daily, consider a starting dose of 26/24 mg if systolic BP lt;110 mmHg.
One of the following licensed pharmacy from the nearest location will deliver Uperio tablet 100 mg 28’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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