Zipazom Injection 500 mg 1 Vial

 138.72

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 500 mg
Drug Form : Injection
Pack Size : 1 vial
Does this requires a prescription ?Yes

Zipazom Injection contains Cefoperazone | belongs to Cephalosporin

SKU: pg_25188_35046 Categories: ,

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    How it works

    Zipazom Injection 500 mg 1 Vial works by interfering with the bacterial cell wall formation and thus stops the growth of bacteria.

    Side effects

    Major & minor side effects for Zipazom Injection 500 mg 1 Vial

    • Hypersensitivity severe
    • Seizures severe
    • Pseudomembranous colitis severe
    • Diarrhea
    • Nausea and vomiting
    • Itching or rash
    • Unusual bleeding severe
    • Neutropenia severe
    • Pain at the injection site
    • Injection site Thrombophlebitis
    • Superinfection

    Uses of Zipazom Injection 500 mg 1 Vial

    What is it prescribed for?

    • Respiratory Tract Infection

      This medicine is used in the treatment of respiratory tract infections caused by Staphylococcus aureus, Escherichia coli, Klebsiella species, Proteus mirabilis, Enterobacter species, Hemophilus or S.pneumoniae.

    • Urinary Tract Infection

      This medicine is used in the treatment of urinary tract infections caused by Escherichia coli and Pseudomonas aeruginosa.

    • Bacterial Septicemia

      This medicine is used in the treatment of bacterial septicemia caused by S.pneumoniae, E.coli, and Klebsiella species.

    • Skin and Skin Structure Infection

      This medicine is used in the treatment of skin and skin structure infections caused by Staphylococcus aureus (penicillinase producing and non-penicillinase producing species) and Pseudomonas aeruginosa.

    • Gynecological infections

      This medicine is used in the treatment of gynecological infections like endometriosis or pelvic inflammatory disease caused by E.coli, S. epidermidis, and anaerobic gram-positive cocci.

    Concerns

    Frequently asked questions

    • Onset of action

      The effect of this medicine can be observed rapidly after administration of the dose through the intramuscular (IM) or the intravenous (IV) route.

    • Duration of Effect

      The effect of this medicine lasts for an average duration of 12 hours after IM or IV administration.

    • Safe with Alchohol?

      Use of Zipazom Injection 500 mg 1 Vial within 48-72 hours of alcohol ingestion may cause a disulfiram like-reaction. This reaction is characterized by severe vomiting, abdominal pain, headache, palpitations, difficulty in breathing, sweating, and an increased heart rate. Consumption of alcohol is not recommended during treatment with this medicine and for several days after the therapy has been stopped. Any unusual symptoms should be reported to the doctor on priority.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Usage in pregnancy?

      Use of this medicine in pregnant women is not recommended unless absolutely necessary. Discuss with the doctor all the potential benefits and risks before receiving this medicine.

    • Usage while breast-feeding?

      This medicine may be used in breastfeeding women if necessary. Discuss all the risks and benefits with your doctor before receiving this medicine. If the medicine is used, the breastfed infant should be monitored closely for any adverse effects.

    When not to use?

    • Allergy

      This medicine is not recommended for use in patients with a known allergy to Zipazom Injection 500 mg 1 Vial or any other medicines of the cephalosporin or beta-lactam class of antibiotics.

    Warnings

    Warnings for special population
    • Pregnancy

      Use of this medicine in pregnant women is not recommended unless absolutely necessary. Discuss with the doctor all the potential benefits and risks before receiving this medicine.

    • Breast-feeding

      This medicine may be used in breastfeeding women if necessary. Discuss all the risks and benefits with your doctor before receiving this medicine. If the medicine is used, the breastfed infant should be monitored closely for any adverse effects.

    General Warnings
    • Allergy

      This medicine is not recommended for use in patients with a known allergy to Zipazom Injection 500 mg 1 Vial or any other medicines of the cephalosporin and beta-lactam class of antibiotics. Seek immediate medical attention if you experience any allergic symptoms such as a rash; itching; nausea or vomiting; or swelling of the lips, hands, and feet.

    • Drug resistance

      Usage of Zipazom Injection 500 mg 1 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

    • Clostridium difficile-associated Diarrhea

      Clostridium difficile-associated Diarrhea

    • Impaired kidney function

      This medicine should be used with caution in patients suffering from any kidney disease. Appropriate dose adjustments are to be made based on CrCl.

    • Hepatic/biliary obstruction

      This medicine should be used with extreme caution in patients with a known history of liver diseases or active liver diseases. Since this medicine is excreted mainly through bile, a hepatic or biliary obstruction may increase the levels of Zipazom Injection 500 mg 1 Vial by 2-4 folds. The daily dose should not exceed 4 g for such patients. If a dose of more than 4 g is required, close monitoring of serum concentrations of the medicine and liver function is advised.

    Dosage

    • Missed Dose

      The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed one.

    • Overdose

      The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed one.

    Interactions

    Interaction with Medicines
    • The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed one. severe
    • Loop diuretics severe
    • Anticoagulants severe
    Disease interactions
    • Information not available.

    Lab interactions

    General Instructions

    This medicine should be taken under the supervision of a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine before the completion of the entire course.

    Other details

    • Usage does not depend on food timings
    • To be taken as instructed by doctor
    • Does not cause sleepiness

    References

    Additional Information>

    How to use Zipazom Injection 500 mg 1 Vial

    IM: Inject deep IM Into large muscle mass. IV: Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min. IV Detail: pH 4.5-6.5.
    Reconstitution: IV: Reconstitute with required amount of diluent. Then further dilute in compatible solution. IM: Reconstitute drug with bacteriostatic water for injection (that contains benzyl alcohol or parabens) or SWFI. After reconstitution, let foam dissipate and inspect the solution to ensure complete dissolution.
    Compatibility: Bacteriostatic water for injection, D5LR, D51/4 NS, D5NS, D5W, D10W, LR, NS and SWFI.
    Stability: Prior to reconstitution, store at room temperature. Protect from light. Reconstituted and IV infusion in NS or D5W solution are stable for 24 hours at room temperature, 5 days when refrigerated or 3 weeks, when frozen. After freezing, thawed solution is stable for 48 hours at room temperature or ten days when refrigerated.

    what are the adverse effects of Zipazom Injection 500 mg 1 Vial?

    Diarrhoea, rash, decreased neutrophils, haemoglobin, haematocrit, eosinophilia, increased transaminases.

    What happens if I miss a dose of Zipazom Injection 500 mg 1 Vial?

    Adults: 1-2 gm twice daily IM or IV. By IV adult dose may be doubled. Max 9 gm daily in divided doses. Children & Infants: 50-200 mg/kg/day given in two or more administrations. For neonates (less than 8 days), the drug should be given every 12 hr.

    One of the following licensed pharmacy from the nearest location will deliver Zipazom Injection 500 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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