₨ 272.72
MBBS
Zotonix Injection 40 mg 1 Vial
- Does this requires a prescription ? Yes
- Generic Name: Pantoprazole
- Manufactured by : CCL Pharmaceuticals
- Drug Strength : 40 mg
- Drug Form : Injection
- Pack Size : 1 vial
- Product SKU : pg_25364_35327
Zotonix Injection contains Pantoprazole | belongs to Proton pump inhibitor
Alternate brands of Zotonix Injection 40 mg 1 Vial
Brand Name | Price | Savings |
---|---|---|
Zotonix tablet 40 mg 14’s | ₨ 322.14 | You will pay -49.42 more |
Zotec tablet 40 mg 14’s | ₨ 182.00 | You can save 90.72 |
Zopium tablet 40 mg 14’s | ₨ 245.00 | You can save 27.72 |
Zopent Injection 40 mg 1 Vial | ₨ 250.00 | You can save 22.72 |
Zopent tablet 40 mg 20’s | ₨ 540.00 | You will pay -267.28 more |
How it works
Zotonix Injection 40 mg 1 Vial works by interfering with the final step of acid release in the stomach. This helps in reducing the acidity in the stomach.
Side effects
Major & minor side effects for Zotonix Injection 40 mg 1 Vial
- Headache
- Altered sense of taste
- Runny Nose and Cough
- Diarrhea
- Nausea or Vomiting
- Unusual tiredness and weakness
- Skin Rash severe
- Anorexia
- Injection site Thrombophlebitis
Uses of Zotonix Injection 40 mg 1 Vial
What is it prescribed for?
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Erosive Esophagitis
Zotonix Injection 40 mg 1 Vial is used in the treatment of inflammation and severe ulcers of the esophagus caused by chronic acidity.
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Gastroesophagal Reflux Disease
Zotonix Injection 40 mg 1 Vial is used in the treatment of reflux disease, where acid from the stomach enters and irritates the food pipe (esophagus).
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Helicobacter pylori Infection
Zotonix Injection 40 mg 1 Vial is used to treat Helicobacter Pylori infection in combination with other drugs.
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Zollinger-Ellison Syndrome
Zotonix Injection 40 mg 1 Vial is used to treat a condition where an excessive amount of acid is produced in the stomach due to tumors in the small intestines.
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Gastro-duodenal ulcers
Zotonix Injection 40 mg 1 Vial is used to treat ulcers in the stomach (gastric) and small intestines (duodenal). It is also used to prevent ulcers caused due to stress.
Concerns
Frequently asked questions
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Onset of action
Zotonix Injection 40 mg 1 Vial is rapidly absorbed from the gastro-intestinal tract and reaches its peak levels after 2 to 2.5 hours of oral administration.
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Duration of Effect
Zotonix Injection 40 mg 1 Vial remains active in the body for up to 24 hours after the administration of the dose.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Usage in pregnancy?
No habit-forming tendencies were reported.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Zotonix Injection 40 mg 1 Vial or any other drug of the same group, i.e. Benzimidazoles.
Warnings
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Pregnancy
This medicine is considered safe for consumption by pregnant women. However, discuss all the risks and benefits with your doctor before using this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
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Allergic Reactions
This medicine is not recommended for use in patients with a known allergy to Zotonix Injection 40 mg 1 Vial or any other drug of the same group, i.e. benzimidazoles since it may cause severe allergic reactions. This risk is especially higher if the drug is administered intravenously.
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Heartburn
Zotonix Injection 40 mg 1 Vial does not give instant relief from heartburn. Hence, it is not effective in treating acute heartburn symptoms.
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Liver Disease
Zotonix Injection 40 mg 1 Vial should be used with caution in patients with active liver diseases or a history of liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Bone Fractures
Use of high doses of Zotonix Injection 40 mg 1 Vial for a prolonged duration may increase the risk of bone fractures. This risk is especially higher in the elderly population and in women. Appropriate calcium and vitamin D supplementation may be required in some cases to reduce this risk.
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Vitamin B-12 Deficiency
Long-term treatment with Zotonix Injection 40 mg 1 Vial may decrease the absorption of Vitamin B12 in the body. This may cause vitamin B12 deficiency and associated symptoms. Appropriate vitamin B12 supplementation may be necessary based on the clinical condition.
Dosage
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Missed Dose
Oral forms: The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Injection: Since Zotonix Injection 40 mg 1 Vial injection is usually administered by a qualified healthcare professional in a clinical setting, the likelihood of missing a dose is very low.
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Overdose
Oral forms: Seek emergency medical treatment or contact your doctor in case of an overdose. Injection: Since this medicine is usually administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
Interactions
Interaction with Medicines- Ketoconazole moderate
- Methotrexate severe
- Warfarin moderate
- Nelfinavir severe
- Digoxin moderate
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moderate
Zotonix Injection 40 mg 1 Vial should be used with caution in patients with a history of liver diseases or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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moderate
Zotonix Injection 40 mg 1 Vial should be used with extreme caution in patients with a history of osteoporosis due to the increased risk of fractures. This risk is especially higher with a high dose and prolonged use. Appropriate dose adjustments, clinical monitoring, or replacement with a suitable alternative may be required based on the clinical condition.
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moderate
Zotonix Injection 40 mg 1 Vial should be used with caution in patients who are prone to magnesium imbalances since it increases the risk of low magnesium levels. Report any unusual symptoms to the doctor immediately. Regular monitoring of magnesium levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
General Instructions
Oral forms: Take Zotonix Injection 40 mg 1 Vial with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. Injection: Zotonix Injection 40 mg 1 Vial should be administered by a qualified healthcare professional for the prescribed duration only after a test dose. Report any unusual symptoms to the doctor immediately.
Other details
- Can be taken with or without food, as advised by your doctor
- To be taken as instructed by doctor
- Does not cause sleepiness
References
- practo.com - Pantoprazole [Internet]. Available from: https://www.practo.com/medicine-info/pantoprazole-218-api [cited 07 september 2019]. 14 Dec 2017
- pubchem.ncbi.nlm.nih.gov - Pantoprazole [Internet]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/4679#section=Top [cited 07 september 2019]. 2004., p. 2210
- dailymed.nlm.nih.gov - PROTONIX [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48f4d638-d2a1-47fa-9a81-3acda1b1b1e3 [cited 07 september 2019]. May 13, 2019
How to use Zotonix Injection 40 mg 1 Vial
IV: Infuse over 15 min at a rate not to exceed 3 mg/min. Use in-line filter (positioned below Y-site if use). Flush IV line with D5W, NS, or lactated Ringer’s injection before and after giving drug.
Reconstitution: Reconstitute each 40 mg vial with 10 mL 0.9% NaCl and dilute with 100 mL infusion fluid, give 40 mg over 15 min. Use within 12 hrs.
Compatibility: Intermittent infusion in 5% Glucose or 0.9% NaCl.
Y-site administration:
Drug to Drug IV Compatibility: Azithromycin, bumetanide, ceftriaxone, imipenem, phenylephrine, vasopressin.
Drug to Drug IV Incompatibility: Aztreonam, cefepime, ciprofloxacin, dexamethasone, diltiazem, diphenhydramine, dobutamine, esmolol, famotidine, fentanyl, fluconazole, labetalol, levofloxacin, linezolid, lorazepam, methylprednisolone, metronidazole, midazolam, ondansetron.
Stability: Store at 2°C-8°C. Solution may be stored up to 2 hours before further dilution and up to 22 hours before use.
what are the adverse effects of Zotonix Injection 40 mg 1 Vial?
Nausea, headache, diarrhoea, constipation, skin rashes, fundic gland polyps. Report of subacute cutaneous lupus erythematosus.
What happens if I miss a dose of Zotonix Injection 40 mg 1 Vial?
ORAL: Adults: Duodenal ulcer: 40 mg daily in the morning for 2 wk. Extend for a further 2 wk if not healed.
Gastric ulcer: 40 mg daily in the morning for 4 wk. Extend for a further 4 wk if not healed.
NSAID ulceration: 20 mg daily.
Zollinger-Ellison syndrome: Initially 80 mg daily, adjust dose according to gastric acid secretion.
GERD: 20-40 mg daily in the morning for 2-4 wk. Extend for a further 4 wk if not healed. Maintenance, 20 mg daily; reassess risk/benefit if treatment exceeds 1 yr.
Control of recurring symptoms in healed reflux disease: 20 mg once daily when required.
Triple therapy vs H. Pylori: 40 mg twice daily with either clarithromycin 250 mg and metronidazole 400 mg both twice daily for one wk or clarithromycin 500 mg and amoxicillin 1 gm both twice daily for one wk.
Children: Not recommended.
INJECTION: Adults: Duodenal ulcer, gastric ulcer, reflux oesophagitis: IV: 1 vial/day.
Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions: IV: Initially 80 mg/day. Thereafter, dosage can be titrated up or down as needed using measurements of gastric acid secretion as guide. For rapid acid control: Initially 2 x 80 mg IV to manage a decrease in acid output (lt;10 mEq/hr) within one hr. As soon as oral therapy is possible discontinue IV treatment.
Children: Not recommended.
One of the following licensed pharmacy from the nearest location will deliver Zotonix Injection 40 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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