Amecide tablet DS 400 mg 2×10’s

 20.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 400 mg
Drug Form : Tablet DS
Pack Size : 2x10s

20 Tablet DS per pack
10 Tablet DS in each strip
Rs.10 per strip

Amecide tablet DS contains Metronidazole, Inf/Oral | belongs to Nitroimidazole

SKU: pg_959_1171 Categories: ,

Alternate brands of Amecide tablet DS 400 mg 2×10’s

Brand Name Price Savings
Zonid tablet 400 mg 100’s  150.00 You will pay -130 more
Zonid suspension 200 mg 60 mL  32.00 You will pay -12 more
Zolonaf suspension 200 mg 60 mL  20.60 You will pay -0.6 more
Zogyl suspension 200 mg 60 mL  22.00 You will pay -2 more
Zogyl tablet 400 mg 100’s  150.00 You will pay -130 more
List of alternate brands

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How it works

Amecide tablet DS 400 mg 2×10’s works by inhibiting the growth of bacteria and protozoa by interfering with the DNA synthesis.

Side effects

Major & minor side effects for Amecide tablet DS 400 mg 2×10’s

  • Agitation
  • Blurred vision
  • Burning or tingling sensation of hands and feet
  • Confusion
  • Dizziness
  • Headache
  • Nasal congestion
  • Skin Rash
  • Bleeding gums rare
  • Constipation rare
  • Dark urine rare
  • Fast heartbeat rare

Uses of Amecide tablet DS 400 mg 2×10’s

What is it prescribed for?

  • Amebiasis

    This medicine is used for the treatment of amebiasis, a parasitic infection that affects the intestine and also for the treatment of amebic liver abscess (accumulation of pus) caused by Entamoeba histolytica.

  • Trichomoniasis

    This medicine is used in the treatment of trichomoniasis which is a sexually transmitted disease caused by Trichomonas vaginalis.

  • Bacterial Vaginosis

    This medicine is used in the treatment of overgrowth of bacteria in the vagina caused by Lactobacillus species.

  • Bacterial infections

    This medicine is used to treat the infections caused by bacteria in blood, lungs, genital areas caused by Bacteroides fragilis and Clostridium species.

  • Peritonitis

    This medicine is used in the treatment of peritonitis, which is an inflammation of the inner wall lining of the abdomen called peritoneum.

  • Osteomyelitis

    This medicine is used in the treatment of osteomyelitis, which is an infection of the bone caused by bacteria or fungi.

  • Giardiasis

    This medicine is used in the treatment of giardiasis, which is an infection of the small intestine caused by giardia.

  • Sexually transmitted diseases prophylaxis

    This medicine is used in the prevention of diseases which may be transmitted sexually.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed within 2 hours of administration of the dose.

  • Duration of Effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with Alchohol?

    Consumption of alcohol is not recommended in patients with Amecide tablet DS 400 mg 2×10’s. Any symptoms of the fast heartbeat, warmth, headache, and breathing difficulty should be reported to the doctor.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

When not to use?

  • Allergy

    Not recommended in patients with known allergy to Amecide tablet DS 400 mg 2×10’s or other nitroimidazoles.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

  • Breast-feeding

    This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.

General Warnings
  • Blood cell count

    This medicine may lower the blood cell count and may lead to leukopenia, thrombocytopenia, and bone marrow aplasia. Close monitoring of WBC count, platelets is necessary. Discontinue the treatment if any signs of low blood cell count appear.

  • Neurologic Toxicity

    This medicine may cause neurological effects like convulsions and peripheral neuropathy. Inform the doctor if you have any neurological problems. Any symptoms of convulsions, tingling or burning sensation of hands and feet should be reported to the doctor.

  • Impaired liver function

    This medicine may cause liver injury. The baseline of liver enzymes should be obtained before initiating the therapy. Any signs of elevation in the liver enzymes should be informed to the doctor. Discontinue the treatment until the levels reach to normal.

  • Dialysis

    The desired effect of this medicine is not achieved in dialysis patients. It is necessary to schedule the dose for administration after dialysis procedure or supplemental doses can be given after dialysis

  • Chronic therapy

    This medicine should not be used unnecessarily unless instructed by the doctor because it can increase the risk of developing resistance to this medicine and it can increase the risk of additional infections.

  • Driving or Operating machinery

    Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dosage

  • Missed Dose

    If you miss a dose of Amecide tablet DS 400 mg 2×10’s, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Warfarin severe
  • Ethinyl Estradiol moderate
  • Atorvastatin moderate
  • Disulfiram moderate
  • Phenytoin moderate
  • Lithium moderate
Disease interactions
  • severe

    This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, due to the increased risk of worsening of the patient's condition. Report any incidence of severe or persistent diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • severe

    This medicine should be used with caution in patients with low blood counts or bone marrow depression due to the increased risk of leukopenia, thrombocytopenia, etc. Regular monitoring of complete blood count is necessary for such patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • severe

    This medicine should be used with caution since it may increase the risk of nervous system toxicity which may include convulsions and peripheral neuropathy. Report any symptoms of numbness, tingling or burning sensation of hands and feet to doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

  • severe

    This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

General Instructions

Take Amecide tablet DS 400 mg 2×10’s as advised by your doctor. Do not take in larger amounts than advised. It is advised to take this medicine at the same time every day. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information>

How to use Amecide tablet DS 400 mg 2×10’s

Administered by continuous intravenous infusion or by intermittent IV infusion over one hour. Do not give by direct IV injection. Do not administer IV metronidazole with aluminum needles or hubs or through same IV line as other drugs.
Compatibility: Stable in D5W, NS.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, cephazolin, cefepime, ceftriaxone, cimetidine, ciprofloxacin, cisatracurium, diltiazem, dopamine, enalapril, esmolol, fluconazole, heparin, hydrocortisone, hydromorphone, labetalol, levofloxacin, linezolid, lorazepam, magnesium sulphate, methylprednisolone, midazolam, milrinone, morphine, piperacillin/tazobactam, vasopressin.
Drug to Drug IV Incompatibility: Amphotericin B cholesteryl sulphate complex, aztreonam, filgrastim, lansoprazole, meropenem, pantoprazole, warfarin.
When admixed: Incompatible with aztreonam, dopamine, meropenem.
Stability: It is ready-to-use clear colourless solution stored at controlled room temperature and protected from light.

what are the adverse effects of Amecide tablet DS 400 mg 2×10’s?

Gl disturbance, furred tongue, unpleasant taste. Leucopenia, urticaria, angioedema, CNS disturbances, dark urine. Neuropathy and epileptiform seizures on long term therapy.

What happens if I miss a dose of Amecide tablet DS 400 mg 2×10’s?

Adults: Infections due to anaerobic pathogens: ORAL: 400 mg three times daily. INJECTION: 500 mg eight hourly by IV infusion then oral therapy.
Invasive intestinal diseases in susceptible subjects: ORAL: 800 mg three times daily for five days: less susceptible subjects: 400 mg three times daily for five to ten days.
Hepatic diseases, including amoebic liver abscess and hepatitis and other forms of extra-intestinal amoebic disease: ORAL: 400 mg three times daily for five days.
Pelvic inflammatory disease: ORAL: 400 mg twice daily for 14 days.
Symptomless cyst passers: ORAL: 400-800 mg three times daily for five to ten days.
Acute ulcerative gingivitis: ORAL: 200 mg three times daily for three days.
Acute oral infections: ORAL: 200 mg every 8 hr for 3-7 days.
Leg ulcers and pressure sores: ORAL: 400 mg every 8 hr for 7 days.
Trichomoniasis/Non-specific vaginitis: ORAL: 400 mg twice daily for 7 days or 200 mg three times daily for seven days or 800 mg in the morning and 1200 mg at night for two days or 2 gm as a single dose. Treat male partner concurrently.
Surgical prophylaxis: ORAL: 400-500 mg 2 hr before surgery; up to 3 further doses of 400-500 mg may be given every 8 hr for high-risk procedures. INJECTION: By IV infusion 500 mg up to 30 minutes before the procedure, further 3 doses of 500 mg every 8 hr may be given for high-risk procedures.
Children: Anaerobic infections (usually treated for 7 days and for 10-14 days in Clostridium difficile infection): ORAL: 1-2 mth, 7.5 mg/kg every 12 hr; 2 mth-12 yr, 7.5 mg/kg, max 400 mg, every 8 hr; 12-18 yr, 400 mg every 8 hr. INJECTION: By IV infusion over 20-30 minutes. Neonate less than 26 wk corrected gestational age, 15 mg/kg as a single loading dose followed after 24 hr by 7.5 mg/kg daily; Neonate 26-34 wk corrected gestational age, 15 mg/kg as a single loading dose followed after 12 hr by 7.5 mg/kg every 12 hr; Neonate over 34 wk corrected gestational age, 15 mg/kg as a single loading dose followed after 8 hr by 7.5 mg/kg every 8 hr; 1-2 mth, 15 mg/kg as a single loading dose followed after 8 hr by 7.5 mg/kg every 8 hr; 2 mth-18 yr, 7.5 mg/kg, max 500 mg, every 8 hr.
Pelvic inflammatory disease: ORAL: 12-18 yr, 400 mg twice daily for 14 days.
Acute ulcerative gingivitis and other acute dental infections: ORAL: 1-3 yr, 50 mg every 8 hr; 3-7 yr, 100 mg every 12 hr; 7-10 yr, 100 mg every 8 hr; 10-18 yr, 200-250 mg every 8 hr.
Fistulating Crohn’s disease: ORAL: 1 mth-12 yr, 30 mg/kg, max 500 mg, 2 hr before the procedure. 12-18 yr, 400-500 mg 2 hr before the procedure; up to 3 further doses of 400-500 mg may be given every 8 hr for high-risk procedures. INJECTION: By IV infusion: Neonate under 40 wk corrected gestational age, 10 mg/kg up to 30 minutes before the procedure; Neonate over 40 wk corrected gestational age, 20-30 mg/kg up to 30 minutes before the procedure; 1 mth-12 yr, 30 mg/kg, max 500 mg, up to 30 minutes before the procedure; 12-18 yr, 500 mg up to 30 minutes before the procedure; up to 3 further doses of 500 mg may be given every 8 hr for high-risk procedures.
Invasive intestinal amoebiasis, extra-intestinal amoebiasis (including liver abscess): ORAL: 1-3 yr, 200 mg 3 times daily for 5 days in intestinal infection and for 5-10 days in extra-intestinal infection; 3-7 yr, 200 mg 4 times daily for 5 days in intestinal infection and for 5-10 days in extra-intestinal infection; 7-10 yr, 400 mg 3 times daily for 5 days in intestinal infection and for 5-10 days in extra-intestinal Infection; 10-18 yr, 800 mg 3 times daily for 5 days in intestinal infection and for 5-10 days in extraintestinal infection.
Urogenital trichomoniasis: ORAL: 1-3 yr, 50 mg 3 times daily for 7 days; 3-7 yr, 100 mg twice daily for 7 days; 7-10 yr, 100 mg 3 times daily for 7 days; 10-18 yr, 200 mg 3 times daily for 7 days or 400-500 mg twice daily for 5-7 days, or 2 gm as a single dose.

One of the following licensed pharmacy from the nearest location will deliver Amecide tablet DS 400 mg 2×10’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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