2 reviews for Cytotrexate tablet 10 mg 100’s
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Cytotrexate tablet 10 mg 100’s
₨ 1,514.27
Manufactured by:Lahore Chemical & Pharmaceutical works (PVT) LTD
Active Pharmaceutical Ingredient: Methotrexate
Drug Strength: 10 mg
Drug Form : Tablet
Pack Size : 100s
Does this requires a prescription ?Yes
Cytotrexate tablet contains Methotrexate | belongs to Folic acid antagonist
Alternate brands
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How it works
Cytotrexate tablet 10 mg 100’s works by interfering the DNA synthesis and stops the growth of the cells.
Side effects
Major & minor side effects for Cytotrexate tablet 10 mg 100’s
- Diarrhea severe
- Joint pain severe
- Abdominal pain severe
- Swelling of feet or lower legs severe
- Dizziness severe
- Fever with chills severe
- Unusual bleeding severe
- Blurred vision severe
- Temporary Hair Loss
- Loss of appetite
- Nausea or Vomiting
- Pale skin
- Skin rash
Uses of Cytotrexate tablet 10 mg 100’s
What is it prescribed for?
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Acute Lymphoblastic Leukemia
Cytotrexate tablet 10 mg 100’s is used in the treatment of cancer of the bone marrow that affects the production of white blood cells.
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Choriocarcinoma
Cytotrexate tablet 10 mg 100’s is used in the treatment of cancer of the women's uterus.
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Meningeal Leukemia
Cytotrexate tablet 10 mg 100’s is used in the treatment of cancer meningitis which is a thin layer that protects the brain and spinal cord.
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Breast cancer
Cytotrexate tablet 10 mg 100’s is used with other medications in the treatment of breast cancer.
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Rheumatoid Arthritis
Cytotrexate tablet 10 mg 100’s is used to relieve the symptoms of inflammation in rheumatoid arthritis.
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Psoriasis
Cytotrexate tablet 10 mg 100’s is used in the treatment of psoriasis which is an autoimmune skin disease.
Concerns
Frequently asked questions
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Onset of action
The effect of this medicine can be observed in 1 to 2 hours after an oral dose and 30 to 60 minutes after an intramuscular injection.
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Duration of Effect
The effect of this medicine lasts for an average duration of 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.
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Safe with Alchohol?
Consumption of alcohol is not recommended due to the risk of liver injury. Close monitoring of liver enzymes is necessary. Seek immediate medical treatment if any symptoms like lethargy, yellow colored eyes, and skin, abdominal pain appear.
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Is it habit forming?
No habit forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for pregnant women.
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Usage while breast-feeding?
This medicine is not recommended in breastfeeding women.
When not to use?
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Allergy
Not recommended in patients with known allergy to Cytotrexate tablet 10 mg 100’s .
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Pregnancy
Not recommended for pregnant women due to the risk of birth defects.
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Liver disease
Not recommended in patients with the existing liver disease.
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Blood disorder
Not recommended in patients with existing blood diseases.
Warnings
Warnings for special population
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Pregnancy
This medicine is not recommended for pregnant women.
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Breast-feeding
This medicine is not recommended in breastfeeding women.
General Warnings
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Liver injury
This medicine is not recommended in the patients with the liver injury. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.
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Kidney injury
This medicine is not recommended in the patients with the kidney injury. It may cause kidney injury at higher doses. The dose of this medicine should be adjusted based on the CrCl.
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Lung toxicity
This medicine may cause severe lung injuries like pulmonary fibrosis, pulmonary interstitial infiltrates. Any symptoms of breathing difficulty and signs of lung impairment should be informed to the doctor. The treatment should be discontinued if any symptoms appear.
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Blood cell count
This medicine may lower the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary. The baseline of the blood cell count should be obtained before initiation of the treatment. Do not start the treatment if the counts are less.
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Skin reactions
The medicine may cause severe skin reactions stevens-johnson syndrome, skin necrosis, and skin ulceration. Inform the doctor if any symptoms appear. The treatment should be discontinued.
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Gastrointestinal injury
This medicine is not recommended for use in patients with gastrointestinal disorders like diarrhea and ulcerative stomatitis. Inform the doctor if you have any gastrointestinal disorders before initiation of the therapy.
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Infections
The chances of occurring infections are more in the patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.
Dosage
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Missed Dose
It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.
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Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
Interactions
Interaction with Medicines
- Azole antifungal agents moderate
- Atorvastatin moderate
- Live vaccines severe
- Proton pump inhibitors severe
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severe
Cytotrexate tablet 10 mg 100’s is not recommended for the treatment of psoriasis and rheumatoid arthritis in patients with liver disease. The baseline of the liver enzymes should be obtained before starting the therapy. The treatment should be discontinued if liver enzymes are elevated.
General Instructions
Take Cytotrexate tablet 10 mg 100’s as instructed by your doctor. Do not take in larger amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.
Other details
- Can be taken with or without food, as advised by your doctor
- To be taken as instructed by doctor
- May cause sleepiness
References
- practo.com - Methotrexate [Internet]. Available from: https://www.practo.com/medicine-info/methotrexate-177-api [cited 4 octotber 2019]. 16 Nov 2017
- medlineplus.gov - Methotrexate [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a682019.html [cited 4 octotber 2019]. 01 October 2019
- dailymed.nlm.nih.gov - Methotrexate [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec476b11-0b3c-4139-b1eb-a3daa76bc271#a15d5648-439e-4a6d-b23d-1c02c0329aff [cited 4 octotber 2019]. April 1, 2016
It may be administered IM, IV or IT. IV administration may be slow push, short bolus inf or 24-42 hour continuous inf. Dilute powder with D5W or NS to a conc. of = 25 mg/mL (20 mg and 50 mg vials)and 50 mg/mL (1 gm vial). Intrathecal solutions may be reconstituted to 2.5 to 5 mg/mL with NS, D5W, LR or Elliott’s B solution. Use preservative free preparations for IT or high dose administration.
Additional Information
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How to use Cytotrexate tablet 10 mg 100’s
Stability: Store at 20°C-25°C (68°F-77°F); excursions are permitted to 15°C -30°C (59°F-86°F). Protect from light.
what are the adverse effects of Cytotrexate tablet 10 mg 100’s?
Bone marrow depression, GI upset, hepatotoxicity, skin reactions, opportunistic infections, urino-genital disorders, decreased fertility and pulmonary disease and CNS disturbances.
What happens if I miss a dose of Cytotrexate tablet 10 mg 100’s?
Adults: Antineoplastic: Burkitt’s Lymphoma: Stages I-II: Orally: 10-25 mg/day for 4-8 day for several courses; separate by 7-10 day rest period.
Lymphosarcomas: Stage III: Orally: 0.625-2.5 mg/kg/day.
Leukaemia: Induction: 3.3 mg/m² with prednisone every day. Remission Maintenance: 15 mg/m² Orally/IM twice wkly or 2.5 mg/kg IV every 14 day.
Mycosis fungoides: 5-50 mg every wk. If poor response, give 15-37.5 mg twice wkly.
Osteosarcoma: Initial: 12 gm/m² IV, increase to 15 gm/m² if peak levels of 1000 micro-molar not reached at end of infusion.
Choriocarcinoma/trophoblastic diseases: Orally/IM: 15-30 mg every day x 5 day, rest gt;1 wk & repeat 3-5 times.
Rheumatoid arthritis: Initial: 7.5 mg once wkly or 2.5 mg every 12 hr x 3 doses once wkly. Max: 20 mg/wk. Reduce to lowest effective dose.
Psoriasis: Usual: 10-25 mg/wk Orally/IV/IM until adequate response achieved or use 2.5 mg every 12 hr x 3 doses. Titrate: May increase gradually. Max: 30 mg/wk.
Children: Meningeal leukaemias: Intrathecal: Dilute preservative free Methotrexate to 1 mg/mL. Dose every 2-5 day. gt;3 yr: 12 mg. 2 yr: 10 mg. 1 yr: 8 mg. lt;1 yr: 6 mg.
Juvenile rheumatoid arthritis: Children 2-16 yr: 10 mg/m² once wkly. Adjust dose to optimal response.
One of the following licensed pharmacy from the nearest location will deliver Cytotrexate tablet 10 mg 100’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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omar –
omar submitted 5 stars.
kashif –
app is wonderful, but I write my comments after receiving medicine.