Grafro Injection 500 mg 1 Vial
Grafro Injection contains Ceftizoxime | belongs to Cephalosporin
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How it works
Grafro Injection 500 mg 1 Vial exert bactericidal activity by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. They are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.
Frequently asked questions
Onset of action
Duration of Effect
Safe with Alchohol?
Is it habit forming?
Usage in pregnancy?
Usage while breast-feeding?
- antimicrobe.org - Ceftizoxime [Internet]. Available from: http://www.antimicrobe.org/drugpopup/Ceftizoxime.htm [cited 30/6/2020].
- drugs.com - ceftizoxime [Internet]. Available from: https://www.drugs.com/mtm/ceftizoxime.html [cited 90/6/2020].
How to use Grafro Injection 500 mg 1 Vial
IM: Inject deep IM into large muscle mass. IV: Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min.
Reconstitution: IV: Reconstitute with SWFI as follows: For 500 mg vial: Add 5 mL, 1 gm vial: Add 10 mL, 2 gm vial: Add 20 mL. Shake well. Dilute reconstituted solution further with 50-100 mL of a compatible solution, such as NS or D5W before administration. IM: Reconstitute with SWFI as follows: For 500 mg vial: Add 1.5 mL, 1 gm vial: Add 3 mL. 2 gm vial: Add 6 mL. Shake well. Divide 2 gm doses and administer in different sites.
Compatibility: Stable in D5¼NS, D5½NS, D5NS, D5W, D10W, LR, NS, sodium bicarbonate 5%.
what are the adverse effects of Grafro Injection 500 mg 1 Vial?
Pain at inj site, hypersensitivity reactions. Gl disturbances, eosinophilia, neutropenia, leucopenia, thrombocytopenia, rise in liver enzymes and blood urea. Positive Coomb’s test.
What happens if I miss a dose of Grafro Injection 500 mg 1 Vial?
Adults: IM/IV: 1-2 gm every 8-12 hr, up to 2 gm every 4 hr or 4 gm every 8 hr for life-threatening infection. Children: gt; 6 mth: 150-200 mg/kg/day divided every 6-8 hr; max 12 gm/day.
Bone Infection: IM/IV: Adults: 1-2 gm every 8-12 hr. Max: 6 gm/day. Children: gt; 6 mth: 50 mg/kg every 6-8 hr, not to exceed adult dose.
Meningitis/ Septicaemia: IV: Adults: 3-4 gm every 8 hr. Children: gt; 6 mth: 50 mg/kg every 6-8 hr, not to exceed adult dose.
One of the following licensed pharmacy from the nearest location will deliver Grafro Injection 500 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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