₨ 7,000.00
MBBS
IMURAN TABLET 50MG Pack of 100 Tablets (w)
- Generic Name: Azathioprine
- Drug Form : Tablet
- Pack Size : 100 TAB
- Product SKU : TYB_3439
IMURAN contains Azathioprine and is now available in Pakistan. The price of Azathioprine is Rs.7000 as of 1st January 2025 it can be purchased online from MedicalStore.com.pk. The prices are updated regularly on this page.
Alternate brands of IMURAN TABLET 50MG Pack of 100 Tablets (w)
| Brand Name | Price | Savings |
|---|---|---|
| Pharmazorine tablet 50 mg 10×10’s | ₨ 1,000.00 | You can save 6000 |
| Imuran tablet 50 mg 10×10’s | ₨ 7,000.00 | You can save 0 |
| Azathioprine tablet 50 mg 10×10’s | ₨ 1,210.00 | You can save 5790 |
| Azathioprine Injection 50 mg 1 Vial | ₨ 622.00 | You can save 6378 |
| Azafrine tablet 50 mg 10×10’s | ₨ 1,600.00 | You can save 5400 |
Imuran (azathioprine) is an immunosuppressive medication primarily used to prevent organ rejection in transplant patients and to manage various autoimmune diseases. Each Imuran tablet contains 50 mg of azathioprine, and it is commonly available in packs of 100 tablets.
Mechanism of Action
Azathioprine is a prodrug that is metabolized in the body to its active form, 6-mercaptopurine (6-MP). 6-MP interferes with the synthesis of purine nucleotides, which are essential components of DNA and RNA. By inhibiting purine synthesis, azathioprine suppresses the proliferation of immune cells, particularly lymphocytes, thereby reducing the immune response. This immunosuppressive effect is beneficial in preventing organ rejection and controlling autoimmune diseases.
Indications
Imuran is indicated for:
- Prevention of Organ Rejection: Used as an adjunct therapy to prevent rejection in kidney, liver, and heart transplant recipients.
- Autoimmune Diseases: Management of severe rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, polymyositis, and certain types of vasculitis.
- Inflammatory Bowel Disease: Treatment of moderate to severe Crohn’s disease and ulcerative colitis.
Contraindications
Imuran is contraindicated in patients with:
- Hypersensitivity: Known hypersensitivity to azathioprine or any component of the formulation.
- Pregnancy: Due to potential teratogenic effects, it is contraindicated in pregnant women unless the potential benefits outweigh the risks.
- Thiopurine Methyltransferase (TPMT) Deficiency: Patients with a known deficiency of TPMT are at increased risk for severe toxicity.
Side Effects
Common side effects of Imuran include:
- Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal pain.
- Hematologic Effects: Leukopenia, thrombocytopenia, and anemia due to bone marrow suppression.
- Increased Infection Risk: Due to immunosuppression, there is an elevated risk of infections.
- Hepatotoxicity: Elevations in liver enzymes and, in rare cases, liver damage.
- Hypersensitivity Reactions: Fever, rash, and arthralgia.
Patients should be monitored regularly through blood tests to assess blood cell counts and liver function during treatment.
Pricing in Different Countries
The cost of Imuran 50 mg (pack of 100 tablets) varies across different countries. Below is a table summarizing the approximate prices:
| Country | Approximate Price | Reference |
|---|---|---|
| United States | $72.92 | PharmacyChecker |
| Canada | $68.99 | Canada Drugs Direct |
| United Kingdom | £38.59 | LifeRx Pharmacy |
| Pakistan | ₨8,000 | Online Pharmacy |
| Malaysia | RM301.40 | DoctorOnCall |
Prices are approximate and may vary based on pharmacy, insurance coverage, and local regulations.
Top Global Brands of Azathioprine
Several pharmaceutical companies manufacture azathioprine under different brand names. Here are five notable brands:
- Imuran: Marketed by various companies worldwide, including Aspen Pharmacare and GlaxoSmithKline.
- Azasan: Produced by Salix Pharmaceuticals in the United States.
- Azamun: Available in some European countries, manufactured by Meda Pharmaceuticals.
- Imurel: Marketed in France and other countries by Sanofi-Aventis.
- Azathioprine: Generic versions are available from multiple manufacturers globally.
How it works
IMURAN TABLET 50MG Pack of 100 Tablets (w) works by weakening the immune system to help your body accept the new kidney as if it were your own (in the case of an organ transplant) or to prevent further damage to your joints (in the case of rheumatoid arthritis).
Side effects
Major & minor side effects for IMURAN TABLET 50MG Pack of 100 Tablets (w)
- Fever with chills severe
- Sore throat severe
- Abdominal pain severe
- Loss of appetite severe
- Muscle and joint pain severe
- Nausea and Vomiting
- Hair loss or thinning of the hair rare
Uses of IMURAN TABLET 50MG Pack of 100 Tablets (w)
What is it prescribed for?
-
Kidney Transplantation
IMURAN TABLET 50MG Pack of 100 Tablets (w) is used in kidney transplant patients to prevent transplant rejection.
-
Rheumatoid Arthritis
IMURAN TABLET 50MG Pack of 100 Tablets (w) is used in the treatment of rheumatoid arthritis which is an inflammatory disease characerized by swelling, pain, and stiffness of joints.
When not to use?
-
Allergy
Not recommended in patients with known allergy to IMURAN TABLET 50MG Pack of 100 Tablets (w) .
-
Alkylating agents
Not recommended in patients with rheumatoid arthritis previously treated with cyclophosphamide, chlorambucil.
-
Malignancy
This medicine may increase the risk of lymphoma and other malignancies. Doctors should inform patients about these risks and advise the patient to prevent exposure of the sunlight by wearing protective clothes.
-
Blood cell count
This medicine may lower the blood cell count and may lead to a condition severe bone marrow suppression. Close monitoring of blood cell count is necessary. Any signs of decreased WBC and platelets should be informed to the doctor.
-
Serious infections
The chances of occurring infections are more in the patients receiving this medicine. Hold the treatment and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.
-
Liver impairment
This medicine is not recommended in the patients with the liver impairment. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.
Dosage
-
Missed Dose
If you miss a dose of IMURAN TABLET 50MG Pack of 100 Tablets (w) , take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
-
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
General Instructions
Take IMURAN TABLET 50MG Pack of 100 Tablets (w) as advised by your doctor. Do not take in larger amounts than advised. It is advised to take this medicine at the same time every day. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.
Other details
- To be taken after food
- To be taken as instructed by doctor
- May cause sleepiness
References
- webmd.com - Azathioprine [Internet]. Available from: https://www.webmd.com/drugs/2/drug-13771/azathioprine-oral/details [cited 14/7/2020].
One of the following licensed pharmacy from the nearest location will deliver IMURAN TABLET 50MG Pack of 100 Tablets (w). The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
Questions and Answers
-
Q Can you please tell me the name of the country where this medician made in ?Asked by on November 29, 2019 11:05 pmThere are no answers for this question yet. Answer now
3 reviews for IMURAN TABLET 50MG Pack of 100 Tablets (w)
Tayyab Cheema (verified owner) –
Tayyab Cheema submitted 5 stars.
Rizwan –
Rizwan submitted 5 stars.
Javeriah Naveed –
Javeriah Naveed submitted 5 stars.