₨ 124,706.00
MBBS
Tykerb tablet 250 mg 70’s
- Does this requires a prescription ? Yes
- Generic Name: Lapatinib
- Drug Strength : 250 mg
- Drug Form : Tablet
- Pack Size : 70's
- Product SKU : pg_23238_32166
Tykerb tablet contains Lapatinib | belongs to Protein kinase inhibitor
How it works
Tykerb tablet 250 mg 70’s works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
Side effects
Major & minor side effects for Tykerb tablet 250 mg 70’s
- Decreased appetite or loss of appetite
- Difficulty in breathing
- Stomach pain
- Back pain or Joint pain
- Clay colored stools rare
- Fast or irregular heartbeat
- Yellow eyes or skin
- Dark urine rare
- Headache rare
- Severe diarrhea
- Fatigue
- Skin rash rare
- Nausea or vomiting
Uses of Tykerb tablet 250 mg 70’s
What is it prescribed for?
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HER2- overexpressing advanced or metastatic breast cancer
This medicine is indicated for the treatment of advanced or metastatic breast cancer in combination with capecitabine in patients whose tumors overexpress human epidermal growth factor receptor-2 positive (HER2) and who have progressed after therapy with other anti-cancer agents including an anthracycline, taxane, and trastuzumab.
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Hormone-positive and HER2-positive metastatic breast cancer
This medicine is used in combination with letrozole to treat metastatic breast cancer in postmenopausal women with hormone receptor-positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is necessary.
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Hormone receptor-negative metastatic breast cancer
This medicine is used to treat hormone receptor-negative metastatic breast cancer in patients whose tumors overexpress HER2/neu and who have received prior trastuzumab therapy in combination with chemotherapy.
Concerns
Frequently asked questions
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Onset of action
The amount of time required for this medicine to show its action is not clinically established.
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Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit-forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
When not to use?
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Allergy
This medicine is not recommended for use if you have a known allergy to Tykerb tablet 250 mg 70’s or any other inactive ingredients present along with it.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
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Cardiac disorders
This medicine should be used with caution in patients suffering from any cardiac disorders due to the increased risk of severe adverse effects. Close monitoring of cardiac function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Kidney impairment
This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
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Liver impairment
This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Thrombocytopenia
This medicine should be used with caution in patients with decreased platelet counts due to the increased risk of worsening of the patient’s condition. Regular monitoring of platelet count is necessary prior to each dose of this medicine. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.
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Driving or Operating machinery
Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
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QT interval prolongation
This medicine should be used with extreme caution in patients who have or may develop prolongation of QT interval due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
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Severe cutaneous adverse reactions
This medicine may cause severe cutaneous adverse reactions or life-threatening reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, etc. in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
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Severe diarrhea
This medicine may cause severe diarrhea in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Dosage
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Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
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Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
Interactions
Interaction with Medicines- Clonazepam moderate
- Omeprazole moderate
- Teriflunomide severe
- Digoxin severe
- Cisapride severe
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severe
This medicine should be used with extreme caution in patients with cardiac dysfunction due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
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severe
This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
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severe
This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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moderate
This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
General Instructions
Take this medicine one hour before or after food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Other details
- To be taken on an empty stomach
- To be taken as instructed by doctor
- May cause sleepiness
References
- medlineplus.gov - Lapatinib [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a607055.html [cited 7/9/2020]. 2020
what are the adverse effects of Tykerb tablet 250 mg 70’s?
Diarrhoea, decrease LVEF, rash, GI upsets, stomatitis, anorexia, fatigue, headache, dry skin, hyperbilirubinaemia, hepatotoxicity, back pain, insomnia, mucosal inflammation, cough, dyspnoea, alopecia, pruritus, arrhythmia.
What happens if I miss a dose of Tykerb tablet 250 mg 70’s?
Adults: In combination with capecitabine, 1.25 gm once daily as a single dose. In combination with aromatase inhibitor, 1.5 gm once daily. Counselling: Always take at the same time in relation to food, either 1 hr before or 1 hr after food.
One of the following licensed pharmacy from the nearest location will deliver Tykerb tablet 250 mg 70’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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